Cyclo-epsilon-(L-lysine1, glycine6-bradykinin) (CLGB) and cyclo-epsilon-kallidin have been synthesised in solution. To prepare linear precursors, fragment condensation (3 + 3 or 4) + 3 was used. Peptide bond formation, including cyclization, was carried out mainly through intermediate pentafluorophenyl esters. After purification on silicagel, protected cyclopeptides were obtained with a 50 to 60% yield. The protecting groups were eliminated by treatment with hydrogen fluoride in the presence of anisole. CLGB and CK were purified by droplet countercurrent chromatography and by reversed-phase HPLC, respectively.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The role of M1/M2 macrophage polarization in the pathogenesis of obesity-related kidney disease and related pathologies.
Front Immunol
January 2025
Laboratory of Immunohematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece.
Obesity is a rapidly growing health problem worldwide, affecting both adults and children and increasing the risk of chronic diseases such as type 2 diabetes, hypertension and cardiovascular disease (CVD). In addition, obesity is closely linked to chronic kidney disease (CKD) by either exacerbating diabetic complications or directly causing kidney damage. Obesity-related CKD is characterized by proteinuria, lipid accumulation, fibrosis and glomerulosclerosis, which can gradually impair kidney function.
View Article and Find Full Text PDFComprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis.
Drug Des Devel Ther
January 2025
Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, 272000, People's Republic of China.
Background: Corilagin is widely distributed in various medicinal plants. In recent years, numerous pharmacological activities of Corilagin have been reported, including anti-inflammatory, antiviral, hepatoprotective, anti-tumor, and anti-fibrosis effects. However, there is still a need for systematic metabolomics analysis to further elucidate its mechanisms of action.
View Article and Find Full Text PDFLyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis.
Brain Behav Immun Health
February 2025
University Center for Research and Development, Chandigarh University, Mohali, Punjab, India.
Background And Objective: Lyme disease, caused by , presents major health challenges worldwide, leading to serious neurological and musculoskeletal issues that impact patients' lives and healthcare systems. This systematic review and meta-analysis aim to determine the prevalence and link between Lyme disease and these complications, aiming to enhance clinical and public health approaches.
Methods: We systematically searched PubMed, EMBASE, and Web of Science up until April 01, 2024, to find studies reporting the prevalence and severity of neurological and musculoskeletal complications associated with Lyme disease.
Finite Element Analysis (FEA) for Influence of Variation in Dental Implant Dimensions (Length and Diameter) on Peri-implant Bone Stress/Strain Distribution: A Systematic Review.
Pak J Med Sci
January 2025
Sasankoti Mohan Ravi Prakash, DMD, MDS, BDS Dentist and Independent Researcher, Hope Health Inc, 360 N Irby St. Florence, South Carolina, USA 29501.
Background & Objective: Currently, there are many implants in clinical use, making it hard to choose the right one for the patient. The success rate of an implant depends on its diameter, length, and direction of insertion in bone. In implant dentistry, Finite Element Analysis (FEA) simulates intraoral conditions in vitro and analyzes the effects of implant material, diameter, size, and other components related to oral structure on the implant and peri-implant tissues.
View Article and Find Full Text PDFSmaller sizes of polyethylene terephthalate microplastics mainly stimulate heterotrophic NO production in aerobic granular sludge systems.
Water Res X
May 2025
School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, PR China.
Widespread polyethylene terephthalate microplastics (PET MPs) have played unintended role in nitrous oxide (NO) turnovers (i.e., production and consumption) at wastewater treatment plants (WWTPs).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!