AI Article Synopsis
- Seven genotypic subtypes of a specific pathogen have been identified as distinct species, with subtype 1 being the most associated with human diseases.
- A study examined the clinical characteristics and drug susceptibilities of these subtypes over the past decade at a hospital, finding that about 21.7% of isolates were distinct from the predominant subtype.
- Patients with subtype 1 infections had a significantly higher treatment rate (55.3%) and were more likely to receive surgical intervention compared to other subtypes, which exhibited greater resistance to certain antibiotics.
Article Abstract
Background: Seven genotypic subtypes of were recently demonstrated to represent distinct species based on phylogenomic analysis. sensu stricto (formerly known as subtype 1) is most frequently associated with human diseases; only a few studies have compared the diverse clinical characteristics of subtypes, including their drug susceptibilities. We determined the actual incidence of infections caused by each subtype of and identified their clinical characteristics.
Methods: We subtyped isolates identified as over the last 10 years at a tertiary care hospital. Percent identity score of stored sequencing data was calculated using curated reference sequences of all subtypes. Clinical characteristics were compared between those classified as subtype 1 and other subtypes. Student's -test, Wilcoxon rank-sum test, and Fisher's exact test were used for comparisons.
Results: Overall, 21.7% of the isolates were identified as species distinct from . The proportion of patients with subtype 1 infection who received treatment was significantly higher than that of patients with other subtype infections (55.3% vs. 7.7%, =0.003). Only patients with subtype 1 infection received surgical treatment. Non-subtype 1 isolates showed a higher frequency of resistance to ciprofloxacin and trimethoprim/sulfamethoxazole.
Conclusions: Non-subtype 1 isolates should be separately identified in routine clinical laboratory tests for appropriate treatment selection.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041593 | PMC |
| http://dx.doi.org/10.3343/alm.2021.41.5.463 | DOI Listing |
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