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Evolocumab in metastatic castration-resistant prostate cancer: study protocol for a single-arm, phase II trial, and initial experience with use of a validated lipid biomarker to direct therapy.
Ther Adv Med Oncol
December 2024
Medical Oncology, Chris O'Brien Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia.
Background: Despite advances in the treatment of metastatic castration-resistant prostate cancer (mCRPC), primary and secondary resistance to current therapies remains. Elevated circulating sphingolipids are associated with poor outcomes in patients with mCRPC, including therapeutic resistance and shorter overall survival. PCPro is a clinically accessible, regulatory compliant plasma lipid biomarker of poor prognosis in mCRPC, which incorporates prognostic sphingolipids.
View Article and Find Full Text PDFManagement of Hypercholesterolemia in Patients with Coronary Artery Disease: A Glimpse into the Future.
J Clin Med
December 2024
Interventional Cardiology, Sandro Pertini Hospital, 00157 Rome, Italy.
Cardio-cerebral vascular diseases due to atherosclerosis are still the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B have been identified as the primary factors responsible for the atherosclerotic process, with a causal effect. Many drugs aimed at reducing LDL-C levels are already on the market, acting in different ways in terms of mechanism of action, efficacy, and safety.
View Article and Find Full Text PDFRecommendations for the management of patients with type 2 diabetes at hospital discharge after an ischaemic cardiovascular event.
Hipertens Riesgo Vasc
November 2024
University of Cordoba, Córdoba, Argentina.
Article Synopsis
- The document provides guidelines for managing patients with type 2 diabetes (T2D) after they are discharged from the hospital following a heart event, emphasizing the connection between diabetes and increased heart risks.
- It recommends strict management of cholesterol levels using powerful statins and other medications, along with optimal blood pressure treatment to prevent future issues like heart attacks or strokes.
- Education on nutrition, lifestyle changes, and regular monitoring of treatments are crucial for controlling T2D and minimizing cardiovascular risks, especially focusing on weight management.
Background: Glucose levels are vital for indicating the body's sugar content, with imbalances leading to diseases like diabetes or hypoglycemia-related symptoms such as palpitations and fatigue.
Methods: This case series describes three cases of hypoglycemia identified in recent years, utilizing multiple glucose measurement methods and exploring strategies to eliminate interferences.
Results: Two cases of pseudo-hypoglycemia induced by PEGylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) and Evolocumab injections, and one case of true reactive hypoglycemia following a glucose tolerance test in a patient post-gastric bypass surgery.
A retrospective analysis on optimal medical therapy for patients with symptomatic lower extremity peripheral artery disease: a French observational study.
BMC Cardiovasc Disord
November 2024
Vascular Medicine Unit, CHU Rennes, 2 Rue Henri Le Guilloux, Rennes, 35033, France.
Objective: Patients with symptomatic lower extremity artery disease (LEAD) should have an optimal management in terms of lipid goal [i.e. controlled LDL-cholesterol (LDLc)] and medical treatment (triple therapy with an antiplatelet agent, a statin and an angiotensin-converting enzyme inhibitor or a angiotensin-receptor antagonist).
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