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Durable lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection.
Immunity
December 2024
Department of Biomedicine, University of Basel, 4009 Basel, Switzerland. Electronic address:
To interrogate the role of specific immune cells in infection, cancer, and autoimmunity, immunologists commonly use monoclonal depletion antibodies (depletion-mAbs) or genetically engineered mouse models (GEMMs). To generate a tool that combines specific advantages and avoids select drawbacks of the two methods, we engineered adeno-associated viral vectors expressing depletion mAbs (depletion-AAVs). Single-dose depletion-AAV administration durably eliminated lymphocyte subsets in mice and avoided accessory deficiencies of GEMMs, such as marginal zone defects in B cell-deficient animals.
View Article and Find Full Text PDFCluster randomised controlled trial of double-dose azithromycin mass drug administration, facial cleanliness and fly control measures for trachoma control in Oromia, Ethiopia: the stronger SAFE trial protocol.
BMJ Open
December 2024
Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Introduction: Trachoma is caused by the bacterium (). The WHO recommends the SAFE strategy for trachoma elimination: Surgery for trichiasis, Antibiotics, Facial cleanliness and Environmental improvement. Multiple rounds of SAFE implementation have proven insufficient to eliminate trachoma in Ethiopia, where over 50% of the global trachoma burden remains.
View Article and Find Full Text PDFOsteosarcoma-Targeting Pt Prodrug Amphiphile for Enhanced Chemo-Immunotherapy via Ca trapping.
Acta Biomater
December 2024
Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, China. Electronic address:
Platinum (Pt)-based anticancer agents exhibit a lack of selectivity in the treatment of osteosarcoma, resulting in significant toxicity. Furthermore, immune surveillance withinthe tumor microenvironment impedes the uptake of platinum drugs by osteosarcoma cells. To overcome these challenges, an oxaliplatin-based Pt prodrug amphiphile (Lipo-OXA-ALN) was designed and synthesized by incorporatingan osteosarcoma-targeting alendronate (ALN) alongside a lipid tail.
View Article and Find Full Text PDFThe pine wood nematode (PWN), , is one of the most serious invasive forest pests, responsible for pine wilt disease (PWD). Currently, there are no effective, environmentally friendly control methods available. RNA interference (RNAi) technology has been extensively utilized to screen functional genes in eukaryotes and to explore sustainable pest management approaches through genetic engineering.
View Article and Find Full Text PDFModulating the Coordination Environment of Cu-Embedded Mo ( = S, Se, and Te) Monolayers for Electrocatalytic Reduction of CO to CH: Unveiling the Origin of Catalytic Activity.
Langmuir
December 2024
Department of Chemistry, School of Physical Chemical and Applied Sciences, Pondicherry University, Puducherry 605014, India.
The electrochemical CO reduction reaction (CORR) is a promising approach to alleviating global warming and emerging energy crises. Yet, the CORR efficiency is impeded by the need for electrocatalysts with good selectivity and efficiency. Recently, single-atom catalysts (SACs) have attracted much attention in electrocatalysis and are more efficient than traditional metal-based catalysts.
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