Three new tyramine-type alkamides (-), three new natural products (-), five new -acylated/formylated aporphine alkamides with different ratios of rotational isomers (-), and 20 known alkamides (-) were isolated from an EtOH extract of the stems and leaves of . The absolute configurations of compounds , , and were determined by single-crystal X-ray diffraction analysis. In the biological activity assay, compounds , , and - displayed inhibitory effects against lipopolysaccharide-induced NO release in BV-2 microglial cells, exhibiting IC values of 0.93-45 μM.
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New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from .
J Nat Prod
April 2021
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Three new tyramine-type alkamides (-), three new natural products (-), five new -acylated/formylated aporphine alkamides with different ratios of rotational isomers (-), and 20 known alkamides (-) were isolated from an EtOH extract of the stems and leaves of . The absolute configurations of compounds , , and were determined by single-crystal X-ray diffraction analysis. In the biological activity assay, compounds , , and - displayed inhibitory effects against lipopolysaccharide-induced NO release in BV-2 microglial cells, exhibiting IC values of 0.
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