Uterine adenosarcoma is an uncommon biphasic tumor with benign epithelial and malignant mesenchymal components, often presenting difficulties for morphological diagnosis. We describe 5 cases of adenosarcoma of the uterine corpus and cervix, and vaginal stump in patients aged 46-76 years. Clinical data, ultrasound results, morphological data, including immunohistochemical studies with antibodies to CD10, estrogen and progesterone receptors, desmin, smooth muscle actin, and Ki-67 are presented. Large polypoid mass of the epithelial-mesenchymal structure within the uterine cavity in women of peri - and postmenopausal age require the exclusion of malignancy of the mesenchymal component with searchig for diagnostic criteria - periglandular cuffing of the stromal cells and mitoses.
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Article Synopsis
- Uterine adenosarcoma coexisting with endometrial carcinoma is a rare occurrence, as highlighted by a reported case where imaging initially suggested endometrial carcinoma.
- Following surgery to remove the tumors, histological analysis confirmed the presence of both cancers, and the patient had a successful recovery with no recurrence noted after 10 months.
- The article emphasizes the importance of recognizing specific imaging features, like cystic structures, to avoid misdiagnosis of this uncommon condition.
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