This review outlines the important oral implications of tobacco use. The lining of the mouth (oral mucosa), if exposed to tobacco and its products in a susceptible individual, can develop benign, potentially malignant, and malignant tumours. Treatment and prognosis depend on tumour type, how early it is detected, its size and site in the oral cavity and whether it has spread. Advanced oral squamous cell carcinoma (OSCC) has a 20% 5-year survival rate. Tobacco use also increases the risk of periodontitis, peri-implantitis, caries, alveolar osteitis and halitosis. Although less life threatening than OSCC, these tobacco related conditions create a substantial financial and health burden for individuals and society. Dental practitioners routinely examine the oral cavity for signs of mucosal and tooth changes, are experienced in recognising variations from normal and have established management and referral pathways. They are also ideally positioned to provide brief interventions to assist their patients to quit smoking.
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http://dx.doi.org/10.1111/add.15513 | DOI Listing |
Sensors (Basel)
December 2024
Dental Medicine Faculty, "Iuliu Hatieganu" University of Medicine and Pharmacy, Pasteur 4, 400349 Cluj-Napoca, Romania.
The use of Raman spectroscopy, particularly surface-enhanced Raman spectroscopy (SERS), offers a powerful tool for analyzing biochemical changes in biofluids. This study aims to assess the modifications occurring in saliva collected from patients before and after exposure to cone beam computed tomography (CBCT) and computed tomography (CT) imaging. SERS analysis revealed significantly amplified spectra in post-imaging samples compared to pre-imaging samples, with pronounced intensification of thiocyanate and opiorphin bands, which, together with proteins, dominated the spectra.
View Article and Find Full Text PDFPharmaceutics
December 2024
Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Background/objectives: Nowadays, sustainability efforts focus on extracting natural cosmeceutical ingredients, such as polyphenols, from agri-food waste, for example, black bentonite (BB). The aims of this work were to validate an antioxidant cosmetic ingredient obtained from the waste BB and embed it into an ad hoc designed oromucosal spray intended for oral cavity wellness.
Methods: Focusing on sustainability, the study tested PEG200, propylene glycol, and their mixtures as unconventional and green extraction solvents, aligned with a waste-to-market approach.
Pharmaceutics
November 2024
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Nitazoxanide (NTX) exhibits promising therapeutic potential; its effectiveness is constrained by its low oral bioavailability due to its poor water solubility and limited permeability. This study focused on developing a complex of NTX with β-cyclodextrins (β-CDs), specifically β-CD and hydroxypropyl-β-cyclodextrin (Hβ-CD), to enhance the solubility and antiviral activity of NTX. The formation of the β-CD:NTX in an aqueous solution was verified using UV-visible spectroscopy, confirming a 1:1 inclusion complex.
View Article and Find Full Text PDFNutrients
December 2024
Unidad de Epidemiología de la Nutrición (EPINUT), Departamento de SaludPública, Historia de la Ciencia y Ginecología, Universidad Miguel Hernández (UMH), 03550 Alicante, Spain.
Background/objectives: Our aim was to evaluate the reproducibility and validity of a semi-quantitative food frequency questionnaire (FFQ) for the assessment of usual nutrient and food intakes in children of 18 months old.
Methods: We included 103 toddlers aged 18 months from the Nutrition in Early Life and Asthma (NELA) birth cohort study. A 47-item FFQ was administered twice to parents with a 3-month interval.
Microorganisms
December 2024
Marine Bioprospecting Line, Evaluation and Use of Marine and Coastal Resources Program-VAR, Marine and Coastal Research Institute-INVEMAR, Santa Marta 470006, Magdalena, Colombia.
Mercury pollution is a significant environmental issue, primarily resulting from industrial activities, including gold mining extraction. In this study, 333 microorganisms were tested in increasing mercury concentrations, where 158 bacteria and 14 fungi were able to grow and remain viable at concentrations over 5.0 mg/L of mercuric chloride (II).
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