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Bosutinib for the Treatment of CML-Using it Safely: a Podcast.
Target Oncol
January 2025
Division of Hematology and SCT, Georgia Cancer Centre, Augusta, GA, USA.
Bosutinib is a second-generation tyrosine kinase inhibitor (TKI) approved for use in patients with newly diagnosed Philadelphia chromosome (Ph)-positive chronic phase (CP) chronic myeloid leukemia (CML), as well as Ph-positive CP, accelerated phase, or blast phase (with chemotherapy) CML resistant or intolerant to prior therapy. Clinical trials have shown bosutinib is effective as first-line therapy for patients with CML as well as in later lines of therapy after prior TKI failure. Bosutinib has an established safety profile; however, as with all TKIs approved for the treatment of CML, there are adverse events (AEs) that require management.
View Article and Find Full Text PDFEfficacy, durability and safety of faricimab for patients with neovascular age-related macular degeneration: 48-week results from the phase 3 LUCERNE China subpopulation.
Asia Pac J Ophthalmol (Phila)
January 2025
Peking Union Medical College Hospital, Beijing, China. Electronic address:
Purpose: To evaluate the efficacy, durability and safety of intravitreal faricimab versus aflibercept over 48 weeks in patients with neovascular age-related macular degeneration (nAMD) from the LUCERNE China subpopulation.
Design: LUCERNE (NCT03823300) was a phase 3 global, double-masked, active comparator-controlled trial. The China subpopulation comprised patients from mainland China, Taiwan and Hong Kong.
In this Letter, we propose and experimentally validate a high-fidelity and adaptive forward-phase-based vibration sensing using a Wiener filter (WF). In commercial coherent digital subcarrier multiplexing (DSCM) systems under external cavity lasers (ECLs), frequency-domain pilot tones (FPTs) in subcarrier intervals are employed for dynamic frequency offset estimation (FOE), carrier phase estimation (CPE), and polarization demultiplexing. The phase estimated by the CPE module is processed with the WF to achieve high-fidelity extraction of the vibration-induced phase.
View Article and Find Full Text PDFIn this Letter, we present a novel, to the best of our knowledge, approach for recovering objects directly from the Fraunhofer diffraction integral, where the diffraction field of an object is approximated by the Fourier transform of this object augmented by an additional phase factor. This phase factor at the observation plane is universal for the diffraction fields generated by objects located at the same plane and illuminated by the same monochromatic plane wave. It can be first extracted from dividing the Fraunhofer diffraction field by the Fourier transform of an object reference.
View Article and Find Full Text PDFThis Letter introduces a method for identifying the fast axis and phase retardation of wave plates by means of polarization common-path vortex interferometry. The technique utilizes a composite polarized vortex beam interacting with the wave plate under test. By analyzing the azimuth angle of the dark fringe in the interference pattern, the wave plate's characteristics are accurately extracted.
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