Background: Over time human skin thins and loses elasticity; topical treatments attempt to reverse this process.
Objectives: The aim of this study was to assess the efficacy of TransFORM Body Treatment (TFB) in skin rejuvenation compared to a bland moisturizer on the extensor and volar forearms.
Methods: Blinded participants were given 2 products to apply on the designated forearms with follow-up at 4, 8, and 12 weeks. Measurements included skin thickness, photography, dermatopathology, cutaneous elasticity determined by 2 different methods, and patient-reported outcomes. All were compared to baseline.
Results: Changes between bland moisturizer and TFB were recorded for the following parameters. (1) Roughness: extensor -0.09 mm for bland moisturizer and -0.26 mm for TFB (P = 0.174); volar 0.01 mm for bland moisturizer and -0.23 mm for TFB (P = 0.004). (2) Recoil velocity: volar -56°/sec for bland moisturizer and -24°/sec for TFB (P = 0.61); extensor -95°/sec for bland moisturizer and -63°/sec for TFB (P = 0.57). Retraction speed: volar -3.25 ms for bland moisturizer and -20.08 ms for TFB (P = 0.33); extensor -2.17 ms for bland moisturizer and -10.83 ms for TFB (P = 0.66). Histologically, TFB resulted in an increase in mucopolysaccharide content, new collagen, and number of elastin fibers in the papillary dermis. Changes in the Rao-Goldman score were also observed: volar -0.17 for bland moisturizer and -0.33 for TFB (P = 0.25); extensor -0.08 for bland moisturizer and -0.17 for TFB (P = 0.36).
Conclusions: Histology showed production of new collagen and elastin. Quantification of changes in skin thickness, skin retraction speed, and skin recoil velocity showed trends that agree with the visual data.
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| http://dx.doi.org/10.1093/asj/sjab161 | DOI Listing |
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