AI Article Synopsis
- A direct and specific method was developed to alkylate (sp)C-H bonds using aliphatic boronic acids.
- By heating glycinates and amines with these alkylboronic acids in the presence of oxygen, researchers synthesized various unnatural α-amino acids and peptides.
- This approach allowed for good yields of the desired products, showcasing a new way to create complex organic compounds.
Article Abstract
A direct and site-specific alkylation of (sp)C-H bond with aliphatic boronic acid was achieved. By simply heating glycinates and amines together with alkylboronic acids under an oxygen atmosphere, a variety of unnatural α-amino acids and peptides could be obtained in good yields.
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| http://dx.doi.org/10.1021/acs.orglett.1c00948 | DOI Listing |
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