The natural history and clinical significance of pachydrusen is unclear. This study aims to compare the longitudinal changes of eyes with pachydrusen and soft drusen and progression to exudative macular neovascularisation (MNV). Patients with a diagnosis of MNV in one eye only and the fellow eye was selected as the study eye. Study eyes were required to have pachydrusen or soft drusen on fundus photographs and follow up of at least 2 years or until exudative MNV occurred. Systematic grading was performed at baseline and change in drusen area and onset of exudative MNV recorded over the period of follow up. A total of 75 eyes from 75 patients (29 with pachydrusen and 46 with soft drusen) were included. There was no difference in the rate of progression to exudative MNV in the soft and pachydrusen groups (13.3% versus 24.1%, p = 0.38). Pachydrusen, as compared to soft drusen, was associated with polypoidal choroidal vasculopathy subtype (85.7% versus 16.7%, p < 0.01) and the location of exudation was co-localised with soft drusen but not with pachydrusen. There was a higher rate of increase in soft drusen area compared to pachydrusen area (27.7 ± 31.9%/year versus 8.7 ± 12.4%/year respectively, p < 0.01). We found no difference in the proportion of eyes that developed exudative MNV in this study however characterisation of drusen evolution patterns revealed a strong association with exudative MNV subtype.
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http://dx.doi.org/10.1038/s41598-021-87083-4 | DOI Listing |
Ophthalmol Retina
February 2025
Institut de la Macula,Centro Medico Teknon, Barcelona Spain; Barcelona Macula Foundation, Barcelona, Spain.
Objective Or Purpose: To determine the incidence of spontaneous soft drusen regression without atrophy (DRwoA) in patients with intermediate or atrophic age-related macular degeneration (iAMD, aAMD) and evaluate associated events and offer potential explanations.
Design: A retrospective review of the imaging of a consecutive series of 640 eyes from 320 patients with AMD who had at least 2 years of follow-up.
Subjects: 427 eyes from 262 patients with iAMD or aAMD and no present or past exudative AMD.
Invest Ophthalmol Vis Sci
February 2025
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Purpose: To analyze the relationship between neovascular lesions in polypoidal choroidal vasculopathy (PCV) and vortex vein characteristics.
Methods: Eighty eyes from 77 patients with PCV were examined using widefield swept-source optical coherence tomography (OCT) and indocyanine green angiography. Polypoidal lesions and pigment epithelial detachments (PEDs) were mapped onto choroidal en face OCT images.
Sci Rep
November 2024
Department of Ophthalmology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Aging Dis
October 2024
Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA.
Soft tissue ectopic calcification is due to abnormal accumulation of calcium and phosphate outside the bone. It is the result of the failure of a complex, active, and highly regulated process - much of which is still not well understood. Some of our understanding of ectopic calcification come from studies on diseases such as atherosclerosis, aortic valve disease and kidney stone disease.
View Article and Find Full Text PDFHeliyon
August 2024
Department of Ophthalmology, University of Warmia and Mazury, Oczapowskiego 2, 10-719, Olsztyn, Poland.
of advanced diagnostic methods shed the light on the variable course of age-related macular degeneration (AMD). Despite establishing AMD classifications used in clinical practice, there are still forms of AMD that do not fit into these systems. The case report presents a rare evolution of non-neovascular form of AMD presenting at baseline as large soft drusen.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!