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Single-cell Atlas reveals core function of CPVL/MSR1 expressing macrophages in the prognosis of triple-negative breast cancer.
Front Immunol
December 2024
Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Background: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with the worst prognosis among all subtypes. The impact of distinct cell subpopulations within the tumor microenvironment (TME) on TNBC patient prognosis has yet to be clarified.
Methods: Utilizing single-cell RNA sequencing (scRNA-seq) integrated with bulk RNA sequencing (bulk RNA-seq), we applied Cox regression models to compute hazard ratios, and cross-validated prognostic scoring using a GLMNET-based Cox model.
The aging population presents critical challenges to global healthcare systems, with Japan expected to have 35% of its population aged 65 or older by 2040. Older adults often experience multimorbidity, cognitive impairments, and physical frailties, increasing healthcare utilization and costs. Traditional medical approaches that focus on organ-specific diagnoses are insufficient for addressing these multifaceted needs.
View Article and Find Full Text PDFJaak Panksepp's primary emotions are associated with Diener's global life satisfaction: How low arousal of the SADNESS/separation distress system could form the core of life satisfaction?
Personal Neurosci
November 2024
Department of Molecular Psychology, Institute of Psychology and Education, Ulm University, Ulm, BW, 89081, Germany.
We compared Ed Diener's (SWLS), which was designed as a purely cognitive measure of global life satisfaction, with the , which provides self-report measures of Panksepp's six primary emotions (excluding LUST), in two English-speaking samples: a main sample and a hold-out validation sample. Our data showed robust negative correlations between higher satisfaction with life and lower FEAR, lower SADNESS/Separation Distress, and positive associations (albeit less strong) between higher satisfaction with life and higher PLAY and SEEKING in both samples. The relationships between the SWLS and at least four of Panksepp's primary emotions suggest Diener's SWLS is not purely cognitive and includes a strong affective component.
View Article and Find Full Text PDFContribution of Ryugu-like material to Earth's volatile inventory by Cu and Zn isotopic analysis.
Nat Astron
December 2022
Natural History Sciences, IIL, Hokkaido University; Sapporo 001-0021, Japan.
Initial analyses showed that asteroid Ryugu's composition is close to CI (Ivuna-like) carbonaceous chondrites -the chemically most primitive meteorites, characterized by near-solar abundances for most elements. However, some isotopic signatures (e.g.
View Article and Find Full Text PDFOral health articles in primary care journals: A bibliometric review.
J Public Health Dent
January 2025
Library Education and Clinical Services, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Objectives: Primary care lacks emphasis on oral health (OH) despite its major effects on one's overall health. This mixed-methods bibliometric study was conducted to assess the content of OH in primary care journals.
Methods: Sixty-seven of the most influential journals were identified from primary care specialties and disciplines using Scopus CiteScore metrics and expert opinion.
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