AI Article Synopsis
- Age significantly influences the prognosis of patients with high-grade glioma (HGG), but the genetic reasons for this difference are not fully understood.
- Researchers analyzed data from 1,512 HGG patients across two major cohorts to investigate clinicopathological characteristics, mRNA, mutations, and copy number alterations based on age groups.
- Findings indicate that elderly patients have an altered immune response and show signs of immune suppression, as well as distinct mutation profiles compared to younger patients.
Article Abstract
Background: Age is a powerful prognostic factor of high-grade glioma (HGG). However, the underlying genetic mechanisms of the discrepant prognosis among different age groups remain elusive.
Methods: A total of 953 and 559 HGG patients from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) cohorts were enrolled and assigned as young, intermediate, elderly groups. The data of clinicopathological characteristics, mRNA, mutation, copy number alteration was analyzed.
Results: Transcriptomic analysis revealed that diverse biological processes including immune response are altered between the young and elderly groups. Combined with the analysis of infiltrating immune cells and immune checkpoints, our results suggest an immune suppression status in the elderly group. Patients from different age groups exhibit different mutation and copy number alteration profiles.
Conclusions: A multi-omics analysis is conducted to explore the biological basis of HGG patients of different age groups. This study suggests an immune-suppressive environment in elderly patients.
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| http://dx.doi.org/10.1016/j.clim.2021.108719 | DOI Listing |
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