AI Article Synopsis
- * Their abnormal activity in these cancer cells contributes to aggressive behavior and increased invasiveness, potentially leading to metastasis and death.
- * The review suggests that targeting these sodium channels with existing inhibitors or new treatments could offer promising strategies for cancer therapy.
Article Abstract
Voltage-gated sodium (Na) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial origins such as in breast, lung, prostate, colon, and cervix, whereas they are not expressed in cognate non-cancer tissues. Their activity was demonstrated to promote aggressive and invasive potencies of cancer cells, both and , whereas their deregulated expression in cancer tissues has been associated with metastatic progression and cancer-related death. This review proposes Na channels as pharmacological targets for anticancer treatments providing opportunities for repurposing existing Na-inhibitors or developing new pharmacological and nutritional interventions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010468 | PMC |
| http://dx.doi.org/10.1016/j.isci.2021.102270 | DOI Listing |
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