An atom- and step-economical strategy for the synthesis of bisphosphinoylaminomethanes is reported. This metal-free bisphosphinylation reaction proceeded smoothly through a base-mediated direct 1,1-bisphosphonation of phosphine oxides and isocyanides under mild conditions. The present method offers a facile, efficient, and general approach to a broad range of bisphosphinoylaminomethane derivatives in moderate to good yields.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015124 | PMC |
| http://dx.doi.org/10.1021/acsomega.1c00160 | DOI Listing |
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