Background: The iron/siderophore uptake system (IUS) involved in the pathogenicity. However, IUS's role in antibiotic resistance and the production of -lactamase enzymes of are unclear. This study aimed to investigate the relationship between the production of -lactamase enzymes and IUS regulatory genes in clinical isolates of . isolates were collected from clinical isolates using biochemical tests. The antibiotic resistance patterns and -lactamase-producing strains were identified using the disk diffusion method (DDM). Also, IUS genes were detected by the polymerase chain reaction (PCR) method.
Results: Seventy-two (72) isolates were collected from a different clinical specimen. Gentamicin-resistant strains (43%) had the highest frequency, and aztreonam-resistant strains (12.5%) had the lowest frequency. Also, the distribution of AmpC and MBL producing isolates were 27.7% and 35%, respectively. Moreover, the frequencies of , , , , , , , and genes were as follows: 12.5%, 15.2%, 11.1%, 15.2%, 19.4%, 16.6%, 23.6%, and 6.9%. Further, a strong correlation was observed between the abundance of -lactamase-producing strains and IUS genes.
Conclusions: Based on our knowledge from this study, the association between -lactamase production and IUS genes in plays an essential role in the emergence of drug-resistant strains.
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| http://dx.doi.org/10.1155/2021/5565537 | DOI Listing |
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