AI Article Synopsis
- Nearly 20 years after being identified as a gene linked to Wolf-Hirschhorn Syndrome, the exact role of the LETM1 protein in the inner mitochondrial membrane remains unclear.
- LETM1 is believed to influence key cellular functions like development, respiration, metabolism, and programmed cell death (apoptosis).
- This mini-review discusses the various cellular functions affected by LETM1 and emphasizes its importance in both health and disease contexts.
Article Abstract
Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012663 | PMC |
| http://dx.doi.org/10.3389/fphys.2021.637852 | DOI Listing |
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Article Synopsis
- * IMS contains proteins that are important for triggering apoptosis and managing reactive oxygen species, influencing mitochondrial energy production and cell death pathways through calcium (Ca2+) regulation.
- * The review focuses on different Ca2+ sensors located in the IMS, their mechanisms of action, and how they relate to health conditions and diseases, highlighting their unique properties and functions.
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