Griseb. is a tree endemic to Cuba, occasionally used in herbal medicine. Previously, the antitrypanosomal activity of a -hexane-2-butanone extract of leaves and of its constituent skimmianine were published. In the current study a more thorough examination of the respective extract is performed, which led to the isolation and identification of three flavonoids, more specifically, the flavonol-3--methylethers kaempferol-3--methylether () and novel compounds kaempferol-3--methylether-5---D-glucoside () and kaempferol-8-hydroxy-3,7--dimethylether-5---D-glucoside (). All compounds were screened for their antimicrobial and antiprotozoal activity and cytotoxicity towards MRC-5 SV2 cells. Compound showed a moderate to weak activity against (IC 30.8 μM), (IC 15.4 μM) and (IC 53.8 μM), but also showed cytotoxicity (CC 19.0 μM). Compounds and did not display activity in any of the assays (IC and CC > 64 μM).[Formula: see text].
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