AI Article Synopsis
- The study evaluated the impact of a 15-minute sound intervention on cardiovascular parameters in cancer patients compared to a rest period.
- Cardiovascular metrics such as heart rate variability (HRV) and aortic pulse wave velocity (PWV) showed significant improvements after the sound intervention, indicating beneficial effects on heart health.
- While both rest and sound intervention reduced heart rate, only rest showed a significant increase in systolic aortic blood pressure, highlighting differing effects between the two interventions.
Article Abstract
Background: Music therapy or sound interventions were shown to confer beneficial effects in patients with cancer for instance in terms of pain or fear relief and improvement of other patient reported outcomes. Cardiovascular parameters, especially heart rate variability (HRV) were found to have prognostic implications in cancer patients. In this trial we aimed to investigate the effects of a sound intervention on cardiovascular parameters compared to rest in patients with cancer.
Methods And Results: Using a randomized cross-over design, 52 patients (male 13, female 39) with cancer were recruited to receive both a 15-minute sound intervention and a 15-minute rest intervention within 4 weeks with at least a one-week blanking period. Cardiovascular parameters (among others HRV, aortic pulse wave velocity [PWV], augmentation index [Aix], aortic blood pressure [BP], heart rate [HR]) were assessed immediately before (pre) and after (post) the intervention had taken place. HRV (Root mean square of successive RR interval differences [RMSSD, ms]) significantly increased, during sound intervention (median RMSSD pre 24 [range 5-112] vs post 22 [range 9-141], = .03). Likewise, median PWV, as a direct marker of arterial stiffness, was significantly reduced by sound intervention ([m/s] pre 8.5 [range 5.6-19.6] vs post 8.3 [range 5.6-15.6], = .04). For both parameters no statistically significant change during rest was observed. HR was lowered by both, rest ( < .0001) and sound intervention ( = .02), with a more pronounced effect by rest. A significant increase in systolic aortic blood pressure was shown by rest ([mmHg] median 101 [range 78-150] vs post median 103 [range 71-152], = .04) but not during sound intervention ( = .59), while rest intervention led to a decrease in resistance index (pre median 33 [range 13-92] vs post median 32 [11-84], = .02).
Conclusion: In comparison with rest, a single sound intervention in patients with cancer improved cardiovascular parameters commonly associated with increased stress levels. Studies with longer follow-up and multiple interventions are warranted.
Trial Registration: ISRCTN registry 70947363.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024455 | PMC |
| http://dx.doi.org/10.1177/1534735421995239 | DOI Listing |
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