Precis: Combined average visual field index (VFI) is a simple, novel tool for binocular visual field which agrees with the existing binocular integrated visual field (IVF) model, as well as patient reported activity limitation in glaucoma.
Purpose: The aim was to determine the correlation between novel models of binocular visual field with the existing IVF and glaucoma activity limitation (GAL-9).
Materials And Methods: IVFs were calculated from the monocular visual fields of 58 patients with primary glaucoma and the novel binocular visual field models termed binocular summation visual field index (BiSumVFI) and combined average visual field index (CaVFI) were derived from the VFIs of both fields. GAL-9 questionnaire was administered to the patients. The relationship between IVF and the 2 newer models of binocular fields were determined and the correlation of IVF, BiSumVFI, and CaVFI with GAL-9 was estimated.
Results: A very strong correlation was seen between IVF and BiSumVFI (r=-0.913, P<0.001, confidence interval: -0.958 to -0.821) and also between IVF and CaVFI (r=-0.896, P<0.001, confidence interval: -0.947 to -0.802). Linear regression analysis showed a significant R2 of 0.902 (P<0.001) to predict IVF from BiSumVFI and R2 of 0.847 (P<0.001) to predict IVF from CaVFI. IVF, BiSumVFI, and CaVFI correlated moderately and significantly with GAL-9 with correlation coefficients of 0.481, -0.499, and -0.505, respectively.
Conclusion: The binocular summation VFI and combined average VFI models of binocular visual field are good predictors of IVF in glaucoma. They correlate well with the existing IVF model in estimating patients' perception of activity limitation in glaucoma.
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http://dx.doi.org/10.1097/IJG.0000000000001845 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Mathematics, Western University, London, ON N6A 3K7, Canada.
We study image segmentation using spatiotemporal dynamics in a recurrent neural network where the state of each unit is given by a complex number. We show that this network generates sophisticated spatiotemporal dynamics that can effectively divide an image into groups according to a scene's structural characteristics. We then demonstrate a simple algorithm for object segmentation that generalizes across inputs ranging from simple geometric objects in grayscale images to natural images.
View Article and Find Full Text PDFJ Vis
January 2025
Department of Psychology, University of Washington, Seattle, WA, USA.
The population receptive field (pRF) method, which measures the region in visual space that elicits a blood-oxygen-level-dependent (BOLD) signal in a voxel in retinotopic cortex, is a powerful tool for investigating the functional organization of human visual cortex with fMRI (Dumoulin & Wandell, 2008). However, recent work has shown that pRF estimates for early retinotopic visual areas can be biased and unreliable, especially for voxels representing the fovea. Here, we show that a log-bar stimulus that is logarithmically warped along the eccentricity dimension produces more reliable estimates of pRF size and location than the traditional moving bar stimulus.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Pediatrics, Division of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Alzheimer's disease (AD) is a progressive irreversible dementia characterized by beta-amyloid protein plaque deposition and hyperphosphorylation of tau forming neurofibrillary tangles, and neurodegeneration. An emerging theory posits that infections could be one of the triggering factors in AD development and progression. Multiple lines of evidence have linked Chlamydia pneumoniae (Cp), a gram-negative obligate intracellular bacterium with AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: Employing a custom 60-channel single-transmit/32-channel receive Tic-Tac-Toe (TTT) coil in 7T MRI imaging has enhanced the resolution and contrast for identifying White Matter Hyperintensities (WMHs), which are critical markers in Alzheimer's disease and related dementias (AD/ADRD).
Method: The method involves resecting the left hemisphere of the brain, excluding the cerebellum, followed by embalming in 10% formalin. 1.
Alzheimers Dement
December 2024
Memory & Aging Center, Department of Neurology, University of California in San Francisco, San Francisco, CA, USA.
Background: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized as a separate FTD subtype, a uniform description of the syndrome is still missing. This multicenter study, led by an international working group (IWG), aims to establish a cohesive clinical phenotype and lay the groundwork for consensus on terminology and diagnostic standards.
Method: Retrospective clinical data were systematically collected across 18 dementia centers.
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