Background/aim: Stanniocalcin2 (STC2) is associated with proliferation, invasion, and metastasis in various cancers. We examined the clinical significance of STC2 mRNA expression in patients with colorectal cancer (CRC).
Patients And Methods: Relative expression levels of STC2 mRNA in CRC tissues and corresponding normal mucosa obtained from 202 patients were measured using quantitative real-time reverse transcriptase-polymerase chain reaction.
Results: Expression of STC2 mRNA was higher in the cancer tissue than in the adjacent normal mucosa. STC2 mRNA expression in cancer tissues was associated with tumour size, liver metastasis, venous invasion, and lymph node metastasis. High expression of STC2 mRNA was significantly associated with poorer postoperative survival (p=0.0003). Multivariate analysis showed that high expression of STC2 mRNA was an independent predictor of postoperative survival.
Conclusion: High expression of STC2 mRNA in CRC tissue may be a useful prognostic marker in patients with CRC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.21873/anticanres.14983 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Survival prediction in patients with head and neck squamous cell carcinoma and novel mechanistic insights of S100A8/A9.
Discov Oncol
November 2024
Affiliated Stomatology Hospital of Guilin Medical University, Guilin, 541004, Guangxi, People's Republic of China.
Background: S100A8/A9, an innate immune protein, significantly regulates inflammatory processes and immune responses. While S100A8/A9 has been linked to various diseases, its association with head and neck squamous cell carcinoma (HNSCC) remains unclear.
Methods: Samples from the Cancer Genome Atlas (TCGA) were categorized into groups with low and high expression of S100A8/A9.
CH25H Promotes Autophagy and Regulates the Malignant Progression of Laryngeal Squamous Cell Carcinoma Through the PI3K-AKT Pathway.
Cancer Med
October 2024
Department of Otolaryngology, Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, Zhejiang, China.
Background: Laryngeal squamous cell carcinoma (LSCC) is a type of cancer of the respiratory tract that often presents with subtle symptoms at the early stage and is susceptible to recurrence and metastasis.
Materials And Methods: To find out key regulatory genes involved in LSCC development, we downloaded LSCC-related sequencing datasets for bioinformatics analysis. WGCNA was performed on GSE142083 and differential analysis was conducted on GSE51985 and TCGA-HNSC.
PM dysregulates epithelial barrier function in human corneal epithelial cells that is restored by antioxidant SKQ1.
Toxicol Appl Pharmacol
November 2024
Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, School of Medicine, Detroit, MI 48201, USA. Electronic address:
Article Synopsis
- Exposure to airborne particulate matter less than 10 μm (PM) negatively impacts the barrier integrity of the corneal epithelial cells, leading to reduced protection against environmental pollutants.
- In experiments, both human corneal epithelial cells and mouse models showed that PM exposure decreased important proteins involved in maintaining cell junctions, compromising the overall strength of the corneal epithelial barrier.
- The antioxidant SKQ1 was found to effectively restore the integrity of the epithelial barrier, suggesting that it may be important in preventing eye disorders caused by PM exposure.
STC2 suppresses triple-negative breast cancer migration and invasion by inhibition on EMT and promotion on cell apoptosis.
Discov Oncol
August 2024
Department of Head-Neck and Breast Surgery, Yuebei People's Hospital of Shantou University, Shaoguan, China.
To investigate the effects of higher cellular stanniocalcin 2 (STC2) on suppressing the migration and invasion but promoting the apoptosis of triple-negative breast cancer (TNBC). STC2 in TNBC and the para-carcinoma tissues were analyzed by immunohistochemistry (IHC), while the mRNA level was measured by qPCR. Over-expressing or silencing STC2 was established in MDA-MB-231 cells.
View Article and Find Full Text PDFPalmitic Acid Modulation of the Insulin-Like Growth Factor System in Hypothalamic Astrocytes and Neurons.
Neuroendocrinology
October 2024
Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, Spain.
Introduction: Insulin-like growth factor (IGF)1 and IGF2 have neuroprotective effects, but less is known regarding how other members of the IGF system, including IGF binding proteins (IGFBPs) and the regulatory proteinase pappalysin-1 (PAPP-A) and its endogenous inhibitor stanniocalcin-2 (STC2) participate in this process. Here, we analyzed whether these members of the IGF system are modified in neurons and astrocytes in response to palmitic acid (PA), a fatty acid that induces cell stress when increased centrally.
Methods: Primary hypothalamic astrocyte cultures from male and female PND2 rats and the pro-opiomelanocortin (POMC) neuronal cell line, mHypoA-POMC/GFP-2, were treated with PA, IGF1 or both.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!