Background/aim: Epidemiological studies showed an increased risk of developing laryngeal head and neck squamous cell carcinoma (HNSCC) for employees working in the construction business. This suggested a causal link between exposure to cement particles and development of HNSCC but data were missing.
Materials And Methods: We established an Organisation for Economic Co-operation and Development (OECD) guideline 487-conform micronucleus assay (MNA) using oropharyngeal mucosa-derived primary epithelial cells (OPCs) ex vivo. OPCs from healthy mucosa of 52 donors were cultured in vitro and incubated with serial concentrations of two common cement particles. Mitomycin C was used as a soluble positive control, and TiO and DQ12 were used as negative and positive particle controls. Bi-nucleated cells were counted and the mitotic index (MI) was determined. Subsequently, micronuclei-containing bi-nucleated cells (MN+) were counted.
Results: Cement particles, in concentrations not significantly reducing ex vivo proliferation according to mitotic index, dose-dependently increased micronuclei formation.
Conclusion: Through the establishment of an OECD guideline 487 conform MNA, we demonstrate the mutagenic effects of cement on human OPCs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.21873/anticanres.14951 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hindered Sedimentation of Tungsten Carbide Particles in a Hydroxyl-Terminated Polybutadiene-Based Polymer-Bonded Explosive Energetic Composite System.
J Phys Chem B
January 2025
School of Environment and Safety Engineering, North University of China, Taiyuan, Shanxi 030051, PR China.
Energetic composite systems with uniform particle distributions are of considerable interest, but sedimentation is a persisting challenge. Tungsten carbide (WC, density: 15.36 g/cm) particles are promising cemented carbide particles owing to their desirable properties.
View Article and Find Full Text PDFMesoscale Modeling for Predicting Effective Properties and Damage Behavior of Geopolymer Concrete.
Materials (Basel)
December 2024
School of Engineering, Computing and Mathematics, University of Plymouth, Plymouth PL4 8AA, UK.
Geopolymer concrete is a sustainable construction material and is considered as a promising alternative to traditional Portland cement concrete. However, there is still not much research on the effective properties and damage behavior of geopolymer concrete with consideration of its heterogeneous characteristics by means of mesoscale models combined with the regularized microplane damage model. Here, in this research, an easy and simpler approach for generating concrete mesoscale models and characterizing the angular characteristics of aggregate particles is presented.
View Article and Find Full Text PDFMechanical Properties and Microstructure of Geopolymer-Based PFSS Synthesized from Excavated Loess.
Materials (Basel)
December 2024
CSCEC Strait Construction and Development Co., Ltd., Fuzhou 350015, China.
Pre-mixed fluidized solidified soil (PFSS) has the advantages of pumpability, convenient construction, and a short setting time. This paper took the excavated loess in Fuzhou as the research object and used cement-fly-ash-ground granulated blast furnace slag-carbide slag as a composite geopolymer system (CFGC) to synthesize PFSS. This study investigated the fluidity and mechanical strength of PFSS under different water-solid ratios and curing agent dosages; finally, the microstructure of the composite geopolymer system-pre-mixed fluidized solidified soil (CFGC-PFSS) was characterized.
View Article and Find Full Text PDFOptimizing concrete sustainability with bagasse ash and stone dust and its impact on mechanical properties and durability.
Sci Rep
January 2025
College of Civil Engineering, Department of Bridge Engineering, Tongji University, Shanghai, 200092, China.
Addressing environmental challenges such as pollution and resource depletion requires innovative industrial and municipal waste management approaches. Cement production, a significant contributor to greenhouse gas emissions, highlights the need for eco-friendly building materials to combat global warming and promote sustainability. This study evaluates the simultaneous use of Sugarcane Bagasse Ash (SCBA) and Stone Dust (SD) as partial replacements by volume for cement and sand, respectively, at varying ratios in eco-strength concrete mixes designed for 28 MPa (ES-28) and 34 MPa (ES-34), emphasizing their economic and environmental benefits.
View Article and Find Full Text PDFMicrostructural Characterization of Cellulose Nanocrystals and Microcellulose from Bamboo () for Reinforcing Ordinary Portland Cement Matrix.
Polymers (Basel)
December 2024
Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.
This study investigates the microstructural characterization of cellulose nanocrystals (CNC) and microcellulose (MC) extracted from bamboo fibers () and their potential as reinforcement agents in ordinary Portland cement (OPC) composites. CNC with a mean particle size of 29.3 nm and MC with a mean size of 14.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!