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Do inhaled corticosteroids decrease the risk of cardiovascular outcomes in patients with chronic obstructive pulmonary disease?
Thorax
December 2024
COPD Foundation, Miami, Florida, USA
Background: This study evaluated the quality of cancer recurrence data in the National Cancer Database (NCDB) to determine if missingness and reporting consistency have improved enough to support national research.
Methods: This multi-methods study included NCDB analyses and a cancer registry staff survey. Trends in recurrence data missingness from 2004 to 2021 and multivariable analyses of factors associated with missingness from 2017 to 2021 were evaluated for 4,568,927 patients with non-metastatic cancer.
Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples.
Sci Rep
December 2024
Division of Gastroenterology, University of Mississippi Medical Center, Jackson, MS, USA.
The Paneth cell, a secretory cell of the small intestine, expresses numerous host defense proteins, and is hypothesized to play an important role in host defense against infection. However, studying gene expression in this cell requires invasive procedures. To test the hypothesis that we could observe Paneth cell-specific gene regulation from exfoliated cells in infectious conditions, we obtained stool samples from patients with COVID-19 and uninfected controls.
View Article and Find Full Text PDFA sample size analysis of a mathematical model of longitudinal tumor volume and progression-free survival for Bayesian individual dynamic predictions in recurrent high-grade glioma.
CPT Pharmacometrics Syst Pharmacol
December 2024
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Patients with recurrent high-grade glioma (rHGG) have a poor prognosis with median progression-free survival (PFS) of <7 months. Responses to treatment are heterogenous, suggesting a clinical need for prognostic models. Bayesian data analysis can exploit individual patient follow-up imaging studies to adaptively predict the risk of progression.
View Article and Find Full Text PDFReduction and amalgamation of mercury in silver nanoparticle suspensions under dark conditions.
Chemosphere
December 2024
Department of Chemistry and Biochemistry, Florida International University, Miami, 11200 SW 8th St, Miami, FL 33199, United States; Institute of Environment, Florida International University, 11200 SW 8th St, Miami, FL33199, United States. Electronic address:
Mercury (Hg) is a global pollutant of concern, and its transport and transformation are controlled by various environmental factors, with aquatic particles being an important driver. Understanding the interactions between silver nanoparticles (AgNPs) and Hg under dark condition is a prerequisite for studying the extent of AgNPs interaction with light and its participation in Hg biogeochemical cycling. Herein, under laboratory experimental setting, it was found that the reduction of divalent Hg (Hg(II)) to gaseous elemental Hg (Hg) by AgNPs readily occurred.
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