Objective: To analyze the risk factors affecting hemorrhagic cystitis(HC) after allogeneic hematopoietic stem cell transplantation(allo-HSCT).
Methods: The clinical data of 153 patients underwent allogeneic hematopoietic stem cell transplantation in the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2018 were selected and retrospectively analyzed. The incidence, median time and treatment outcome of HC should be observed. Multivariate analysis was used to observe the risk factors of HC in patients, including sex, age, diagnosis, disease status before transplantation, transplantation type, ATG and CTX in the pretreatment scheme, stem cell source, neutrophil and platelet implantation time; CMV, EBV and BKV infection, and acute graft-versus-host disease(aGVHD).
Results: Among 153 patients underwent allogeneic hematopoietic stem cell transplantation, 25 (16.34%) patients had HC, the median occurance time was 31 days, all patients achieved complete remission after treatment, no bladder irritation and bladder contracture were left. The results of univariate and multivariate Logistic regression analysis showed that the type of transplantation, ATG, CMV viremia before treatment, aGVHD (r=1.036, 3.234, 3.298 and 2.817, respectively) were the independent risk factors of HC.
Conclusion: The urinary BKV detections in the patients with HC are positive, mainly occured during the period from day +13 to days +56. HLA haplotype, pretreatment including ATG, and CMV viremia, and aGVHD are the independent risk factors for HC after allo-HSCT.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2021.02.048 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acute muscle loss in elderly hospitalized patients: Risk factors and adverse clinical outcomes.
Geriatr Nurs
December 2024
Department of Geriatrics, Peking University Third Hospital, Beijing, People's Republic of China. Electronic address:
Objective: To assess muscle loss via ultrasound in the elderly and its link to clinical outcomes and risk factors.
Methods: This retrospective cohort study assessed muscle loss in hospitalized elderly via ultrasound, comparing bilateral anterior thigh thickness (BATT) at admission and after seven days, exploring its relation to hospital-acquired complications (HACs).
Results: In 86 patients (mean age 83.
A cross-sectional study assessing customers' perception, satisfaction, and attitude toward e-pharmacy services in Saudi Arabia.
BMC Health Serv Res
December 2024
Clinical Pharmacy Department, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Background: Electronic pharmacy (e-pharmacy) services are growing rapidly, offering increased accessibility, privacy, and value. Understanding e-pharmacy customer satisfaction, attitudes, and perceptions in Saudi Arabia is crucial for improving the services and enhancing health outcomes. This study aims to examine customers' perceptions, preferences, satisfaction, and experiences with electronic pharmacy services, including community pharmacy e-commerce.
View Article and Find Full Text PDFEffectiveness and cost-effectiveness of a single home-based fall prevention program: a prospective observational study based on questionnaires and claims data.
BMC Geriatr
December 2024
ZHAW Zurich University of Applied Sciences, Winterthur Institute of Health Economics, Winterthur, Switzerland.
Background: Fall prevention programmes are essential interventions in societies with aging populations. This study assessed the fall rate and other health outcomes, as well as the cost-effectiveness of a home-based fall prevention programme for community-dwelling older people. In a single home visit, trained physical or occupational therapists performed fall risk assessments, eliminated environmental risk factors, and provided tailored exercises.
View Article and Find Full Text PDFThe transcription factor YbdO attenuates the pathogenicity of avian pathogenic Escherichia coli by regulating oxidative stress response.
BMC Microbiol
December 2024
College of Agriculture and Forestry, Linyi University, Linyi, 276005, Shandong, China.
Avian pathogenic Escherichia coli (APEC) is a significant pathogen infecting poultry that is responsible for high mortality, morbidity and severe economic losses to the poultry industry globally, posing a substantial risk to the health of poultry. APEC encounters reactive oxygen species (ROS) during the infection process and thus has evolved antioxidant defense mechanisms to protect against oxidative damage. The imbalance of ROS production and antioxidant defenses is known as oxidative stress, which results in oxidative damage to proteins, lipids and DNA, and even bacterial cell death.
View Article and Find Full Text PDFRisk factors for constipation during pregnancy: a multicentre prospective cohort study.
BMC Pregnancy Childbirth
December 2024
Clinic of Obstetrics and Gynaecology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, 03101 Santariskiu Str. 2, LT-08661, Vilnius, Lithuania.
Background: Constipation is frequently encountered in the population of pregnant women. Physical activity and nutritional factors are considered common causes of constipation; however, their impact on this population has not yet been evaluated precisely. This study aimed to assess the prevalence of constipation and its risk factors during pregnancy and postpartum.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!