Objective: To detect the relationship between leukocytes derived microparticle (CD45 MP) and minimal residual disease (MRD) and prognosis of acute myeloid leukemia (AML).
Methods: The expression of CD45 MP, CD44 MP and CD24 MP in peripheral blood of 47 AML patients at the time after induction chemotherapy were detected by using flow cytometry, and the relationship between MP, MRD and prognosis were analyzed.
Results: The percentages of CD45 MP, CD44 MP and CD24 MP in MRD positive group were significantly higher than those in MRD negative group. In MRD positive group, there were positive correlation between CD45 MP, CD44 MP, CD24 MP and MRD level. The AUC of CD45 MP, CD44 MP, CD24 MP in predicting positive MRD was 0.949, 0.782, and 0.817, respectively. The EFS and OS in HCD45 MP, HCD44 MP and HCD24 MP groups were significantly shorter than low level group.
Conclusion: High level of CD45 MP, CD44 MP, CD24 MP can be used to predict high level MRD and poor prognosis.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2021.02.007 | DOI Listing |
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