Structural and functional brain alterations revealed by neuroimaging in CNV carriers.

Curr Opin Genet Dev

Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Psychology, University of California, Los Angeles, USA. Electronic address:

Published: June 2021

Copy Number Variants (CNVs) are associated with elevated rates of neuropsychiatric disorders. A 'genetics-first' approach, involving the CNV effects on the brain, irrespective of clinical symptomatology, allows investigation of mechanisms underlying neuropsychiatric disorders in the general population. Recent years have seen an increasing number of larger multisite neuroimaging studies investigating the effect of CNVs on structural and functional brain endophenotypes. Alterations overlap with those found in idiopathic psychiatric conditions but effect sizes are twofold to fivefold larger. Here we review new CNV-associated structural and functional brain alterations and outline the future of neuroimaging genomics research, with particular emphasis on developing new resources for the study of high-risk CNVs and rare genomic variants.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205978PMC
http://dx.doi.org/10.1016/j.gde.2021.03.002DOI Listing

Publication Analysis

Top Keywords

structural functional
12
functional brain
12
brain alterations
8
neuropsychiatric disorders
8
brain
4
alterations revealed
4
revealed neuroimaging
4
neuroimaging cnv
4
cnv carriers
4
carriers copy
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!