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Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions. | LitMetric

Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions.

Life Sci

Cooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, Durham VA Health Care System, Durham, NC, USA; Durham Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham VA Health Care System, General Internal Medicine and Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

Published: August 2021

AI Article Synopsis

  • This study examines Gulf War Illness (GWI) in U.S. veterans from the Gulf War Era Cohort and Biorepository, using questionnaires collected between 2014 and 2016 to evaluate GWI symptoms and diagnosis criteria.
  • Among deployed veterans, a significant percentage (39.9% met Kansas criteria and 84.2% met CDC criteria) exhibited symptoms of GWI, with deployed veterans showing higher odds of meeting GWI diagnostic criteria compared to non-deployed veterans.
  • The findings indicate a persistent multi-symptom illness in deployed veterans almost 25 years post-war, highlighting the need for updated GWI definitions that reflect aging-related health changes and the potential for a unified GWI case definition for future

Article Abstract

Aims: This study characterizes Gulf War Illness (GWI) among U.S. veterans who participated in the Gulf War Era Cohort and Biorepository (GWECB).

Main Methods: Mailed questionnaires were collected between 2014 and 2016. Self-reported GWI symptoms, symptom domain criteria, exclusionary diagnoses, and case status were examined based on the originally published Kansas and Centers for Disease Control (CDC) definitions in the GWECB cohort (n = 849 deployed to Gulf and n = 267 non-deployed). Associations among GWI and deployment status, demographic, and military service characteristics were examined using logistic regression.

Key Findings: Among deployed veterans in our sample, 39.9% met the Kansas criteria and 84.2% met the CDC criteria for GWI. Relative to non-deployed veterans, deployed veterans had a higher odds of meeting four GWI case status-related measures including the Kansas symptom criteria (aOR = 2.05, 95% CI = 1.50, 2.80), Kansas GWI case status (aOR = 1.42, 95% CI = 1.05, 1.93), the CDC GWI case status (aOR = 1.57, 95% CI = 1.07, 2.29) and the CDC severe criteria (aOR = 2.67, 95% CI = 1.79, 3.99). Forty percent met the Kansas exclusionary criteria, with no difference by deployment status. Some symptoms were nearly universally endorsed.

Significance: This analysis provides evidence of a sustained, multisymptom illness in veterans who deployed to the Persian Gulf War compared to non-deployed Gulf War era veterans nearly 25 years later. Differences in symptoms attributed to GWI by deployment status have diminished since initial reports, suggesting the need to update GWI definitions to account for aging-related conditions and symptoms. This study provides a foundation for future efforts to establish a single GWI case definition and analyses that employ the biorepository.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148241PMC
http://dx.doi.org/10.1016/j.lfs.2021.119454DOI Listing

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