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| http://dx.doi.org/10.1002/acm2.13211 | DOI Listing |
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A dual antioxidant and antimicrobial bioplastic film endowed with amine-branched poly(lactic acid): Bioactive packaging for electron beam sterilization and food shelf-life extension.
Int J Biol Macromol
December 2024
Center of Radiation Processing for Polymer Modification and Nanotechnology (CRPN), Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road., Ladyao, Chatuchak, Bangkok 10900, Thailand; Department of Materials Science, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road., Ladyao, Chatuchak, Bangkok 10900, Thailand. Electronic address:
Cyclic amine-multibranched poly(lactic acid) (mPLA) was prepared as a dual antioxidant and antimicrobial toward PLA active packaging for food shelf-life extension in a case study of bread. The mPLA was coupled with piperidine (PPR) containing a heterocyclic amine derivative, which is a nature-rich bioactive function. The functions of mPLA-PPR enhancing the PLA film performance were studied in comparison with PPR, mPLA and Tinuvin® 770.
View Article and Find Full Text PDFImmune profile diversity is achieved with synthetic TLR4 agonists combined with the RG1-VLP vaccine in mice.
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Cancer ImmunoPrevention Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. Electronic address:
The TLR4 (Toll-like receptor 4)-activating agonist MPLA (monophosphoryl lipid A) is a key component of the adjuvant systems AS01 and AS04, utilized in marketed preventive vaccines for several infectious pathogens. As MPLA is a biologically-derived product containing a mixture of several lipid A congeners with a 4' phosphoryl group and varying numbers of acyl chains with distinct activities, extensive efforts to refine its production and immunogenicity are ongoing; notably, the development of the BECC (Bacterial Enzymatic Combinatorial Chemistry) system in which bacteria express lipid A-modifying enzymes to produce a panoply of lipid A congeners. In an effort to characterize the adjuvant activity of these lipid A congeners, we compared biologically-derived and synthetic versions of BECC470 and BECC438 for adjuvant activity in BALB/c mice vaccinated with the HPV (Human papilloma virus) VLP-based vaccine, RG1-VLP.
View Article and Find Full Text PDFAAPM MPLA case: Betrayal versus disillusionment.
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MD Anderson Cancer Center at Cooper, Camden, New Jersey, USA.
This work of fiction depicts a scenario in which a faculty member felt they were criticized unfairly and inappropriately for honesty on a faculty survey, which reflected poorly on administration. The faculty member was left struggling with how to respond to conflicting feelings and perception of misaligned goals and mission. Simultaneously, the department chair felt they were blindsided by issues that could have been addressed without the embarrassment of a poor survey.
View Article and Find Full Text PDFThe Phenotypic Variability Associated with Hepatocyte Nuclear Factor 1B Genetic Defects Poses Challenges in Both Diagnosis and Therapy.
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Department of Nephrology, University of Crete, 71500 Heraklion, Greece.
The evolving landscape of clinical genetics is becoming increasingly relevant in the field of nephrology. HNF1B-associated renal disease presents with a diverse array of renal and extrarenal manifestations, prominently featuring cystic kidney disease and diabetes mellitus. For the genetic analyses, whole exome sequencing (WES) and multiplex ligation-dependent probe amplification (MLPA) were performed.
View Article and Find Full Text PDFIn Tandem Intragenic Duplication of Doublesex and Mab-3-Related Transcription Factor 1 () in an -Negative Boy with a 46,XX Disorder of Sex Development.
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November 2023
Division of Pediatrics, Department of Obstretics, Gynecology and Pediatrics, Azienda Ospedaliero Universitaria Pisana, 56126 Pisa, Italy.
Disorders of sexual development (DSDs) encompass a group of congenital conditions associated with atypical development of internal and external genital structures. Among those with DSDs are 46,XX males, whose condition mainly arises due to the translocation of onto an X chromosome or an autosome. In the few -negative 46,XX males, overexpression of other pro-testis genes or failure of pro-ovarian/anti-testis genes may be involved, even if a non-negligible number of cases remain unexplained.
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