AI Article Synopsis
- Phytoncide, derived from pinecone waste, shows promising anti-inflammatory and antimicrobial effects, confirmed through animal studies.
- In experiments involving a gastroenteritis rat model and a colitis mouse model, phytoncide supplementation significantly reduced inflammation markers like iNOS and inhibited gastric ulcers and colon shortening.
- These findings suggest that phytoncide could be developed as a functional agent for digestive health, though more research is necessary to fully understand its effects.
Article Abstract
Phytoncide is known to have antimicrobial and anti-inflammatory properties. This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited ( < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group ( < 0.05). Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037037 | PMC |
| http://dx.doi.org/10.3390/molecules26071895 | DOI Listing |
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