AI Article Synopsis
- Ovarian cancer ranks as the seventh most common cancer in women and often has a high mortality rate due to late-stage diagnosis and aggressive behavior.
- Current treatment typically involves surgical removal of tumors followed by platinum-based chemotherapy.
- Recent research indicates that lipid and glucose transporters in ovarian cancer cells could be targeted with inhibitors, offering new avenues for treatment and highlighting their role in cancer progression and metastasis.
Article Abstract
Ovarian cancer is the seventh most common cancer in women. It is characterized by a high mortality rate because of its aggressiveness and advanced stage at the time of diagnosis. It is a nonhomogenous group of neoplasms and, of which the molecular basics are still being investigated. Nowadays, the golden standard in the treatment is debulking cytoreductive surgery combined with platinum-based chemotherapy. We have presented the interactions and the resulting perspectives between fatty acid transporters, glucose transporters and ovarian cancer cells. Studies have shown the association between a lipid-rich environment and cancer progression, which suggests the use of correspondent transporter inhibitors as promising chemotherapeutic agents. This review summarizes preclinical and clinical studies highlighting the role of fatty acid transport proteins and glucose transporters in development, growth, metastasizing and its potential use in targeted therapies of ovarian cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002293 | PMC |
| http://dx.doi.org/10.3390/molecules26061659 | DOI Listing |
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