AI Article Synopsis
- The study developed tri-layered polymer scaffolds mimicking the cartilage structure to restore articular cartilage using different materials and crosslinking methods.
- The impact of bone layer calcium phosphate, intermediate layer polymers, and crosslinking techniques on scaffold properties was thoroughly analyzed, including microstructure and mechanical behavior.
- Results indicated that all scaffold variations exhibit potential for repairing or replacing cartilage tissue in osteoarthritis treatments.
Article Abstract
Polymer-based tri-layered (bone, intermediate and top layers) scaffolds used for the restoration of articular cartilage were prepared and characterized in this study to emulate the concentration gradient of cartilage. The scaffolds were physically or chemically crosslinked. In order to obtain adequate scaffolds for the intended application, the impact of the type of calcium phosphate used in the bone layer, the polymer used in the intermediate layer and the interlayer crosslinking process were analyzed. The correlation among SEM micrographs, physical-chemical characterization, swelling behavior, rheological measurements and cell studies were examined. Storage moduli at 1 Hz were 0.3-1.7 kPa for physically crosslinked scaffolds, and 4-5 kPa (EDC/NHS system) and 15-20 kPa (glutaraldehyde) for chemically crosslinked scaffolds. Intrinsic viscoelasticity and poroelasticity were considered in discussing the physical mechanism dominating in different time/frequency scales. Cell evaluation showed that all samples are available as alternatives to repair and/or substitute cartilage in articular osteoarthritis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999668 | PMC |
| http://dx.doi.org/10.3390/polym13060907 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Therapeutic role of aripiprazole in cartilage defects explored through a drug repurposing approach.
Sci Rep
December 2024
Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea.
Articular cartilage has a limited regenerative capacity, resulting in poor spontaneous healing of damaged tissue. Despite various scientific efforts to enhance cartilage repair, no single method has yielded satisfactory results. With rising drug development costs, drug repositioning has emerged as a viable alternative.
View Article and Find Full Text PDFWood-Derived Hydrogels for Osteochondral Defect Repair.
ACS Nano
December 2024
Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Repairing cartilage tissue is a serious global challenge. Herein, we focus on wood skeletal structures that are highly porous for cell penetration yet have load-bearing strength, and aim to synthesize wood-derived hydrogels with the ability to regenerate cartilage tissues. The hydrogels were synthesized by wood delignification and the subsequent intercalation of citric acid (CA), which is involved in tricarboxylic acid cycles and essential for energy production, and -acetylglucosamine (NAG), which is a cartilage glycosaminoglycan, among cellulose microfibrils.
View Article and Find Full Text PDFA method for comparing MRI sequences of the knee for segmentation based on morphological features.
PLoS One
December 2024
Department of Materials and Production, Aalborg University, Aalborg, Denmark.
Background: In magnetic resonance imaging (MRI) segmentation research, the choice of sequence influences the segmentation accuracy. This study introduces a method to compare sequences. By aligning sequences with specific segmentation objectives, we provide an example of a comparative analysis of various sequences for knee images.
View Article and Find Full Text PDFThe use of autologous chondrocyte transplantation for the treatment of osteoarthritis: a systematic review of clinical trials.
Cell Tissue Bank
December 2024
Division of Shoulder and Elbow Surgery, Rothman Orthopaedic Institute, Philadelphia, PA, USA.
Tissue engineering and cartilage transplantation constitute an evolving field in the treatment of osteoarthritis, with therapeutic and clinical promise shown in autologous chondrocyte implantation. The aim of this systematic review is to explore current clinical trials that utilized autologous chondrocyte transplantation (ACT) and assess its efficacy in the treatment of osteoarthritis. PubMed, Ovid MEDLINE, and Google-Scholar (pages 1-20) were searched up until February 2023.
View Article and Find Full Text PDFComparison of Self-repair Disparities in Articular Cartilage Defect Models With Various Load-bearing Sites.
J Craniofac Surg
December 2024
Department of Endocrinology and Metabolism, West China Hospital, Chengdu, China.
This study aimed to explore the construction of experimental animal models replicating cartilage defects across diverse load-bearing sites, compare self-repair conditions, and examine the role of mechanical stimulation in cartilage self-repair. Experimental animal models were established in rabbits to simulate full-thickness cartilage defects without penetrating the subchondral bone, at various load-bearing sites, including the posterior femoral condyle, anterior femoral condyle and femoral trochlear of knee joint, and the humerus of the shoulder joint. The successful exposure and construction of cartilage defects at the anterior femoral condyle, femoral trochlear, and posterior femoral condyle through the medial extension of surgical incision.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!