Hyperthermia is an adjuvant local anti-cancer treatment using temperatures exceeding the physiologically optimal level, typically 40-43 °C for approximately one hour [...].
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Self-propelling bacteria-based magnetic nanoparticles (BacMags) for targeted magnetic hyperthermia therapy against hypoxic tumors.
Nanoscale
April 2024
Institute of Nano Science and Technology, Knowledge City, Sector 81, Mohali, Punjab-140306, India.
Magnetic hyperthermia-based cancer therapy (MHCT) holds great promise as a non-invasive approach utilizing heat generated by an alternating magnetic field for effective cancer treatment. For an efficacious therapeutic response, it is crucial to deliver therapeutic agents selectively at the depth of tumors. In this study, we present a new strategy using the naturally occurring tumor-colonizing bacteria () as a carrier to deliver magnetic nanoparticles to hypoxic tumor cores for effective MHCT.
View Article and Find Full Text PDFDesign of Magnetic Hydrogels for Hyperthermia and Drug Delivery.
Polymers (Basel)
December 2021
Bar-Ilan Institute for Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels.
View Article and Find Full Text PDFHyperthermia-Based Anti-Cancer Treatments.
Cancers (Basel)
March 2021
Department of Radiation Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.
Hyperthermia is an adjuvant local anti-cancer treatment using temperatures exceeding the physiologically optimal level, typically 40-43 °C for approximately one hour [...
View Article and Find Full Text PDFIn Hyperthermia Increased ERK and WNT Signaling Suppress Colorectal Cancer Cell Growth.
Cancers (Basel)
May 2016
Department of Basic Sciences, The Commonwealth Medical College, Scranton, PA 18509, USA.
Although neoplastic cells exhibit relatively higher sensitivity to hyperthermia than normal cells, hyperthermia has had variable success as an anti-cancer therapy. This variable outcome might be due to the fact that cancer cells themselves have differential degrees of sensitivity to high temperature. We hypothesized that the varying sensitivity of colorectal cancer (CRC) cells to hyperthermia depends upon the differential induction of survival pathways.
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