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Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial. | LitMetric

AI Article Synopsis

  • Chronic Venous Disease (CVD) affects up to 80% of people, leading to symptoms that can impact quality of life.
  • A clinical trial tested a new formulated diosmin (μsmin Plus) on CVD patients to see if it helped relieve symptoms compared to a placebo.
  • Results showed significant improvements in leg swelling, pain, and overall health scores for those taking diosmin, with no reported side effects.

Article Abstract

Chronic Venous Disease (CVD) is a common medical condition affecting up to 80% of the general population. Clinical manifestations can range from mild to more severe signs and symptoms that contribute to the impairment of the quality of life (QoL) of affected patients. Among treatment options, venoactive drugs such as diosmin are widely used in the symptomatic treatment in all clinical stages. The aim of this study is to determine the effectiveness of a new formulated diosmin in relieving symptoms and improving QoL in patients suffering from CVD. In this randomized, double-blind, placebo-controlled, multicenter clinical study, CVD patients with a Clinical-Etiology-Anatomy-Pathophysiology (CEAP) classification system between C2 and C4 were randomized to receive a bioavailable diosmin (as μsmin Plus) 450 mg tablet once daily or a placebo for 8 weeks. Clinical symptoms and QoL were monitored using the measurement of leg circumference, visual analogue scale (VAS) for pain, Global Index Score (GIS) and Venous Clinical Severity Score (VCSS). A total of 72 subjects completed the study. From week 4, leg edema was significantly decreased in the active group ( < 0.001). An improvement in the VAS score was observed in the active group compared to placebo at the end of treatment ( < 0.05). GIS and VCSS scores were significantly improved in the active group at week 8 ( < 0.001). No treatment related-side effects were recorded. The results of this study showed that the administration of low-dose μsmin Plus was safe and effective in relieving symptoms and improving QoL in subjects with CVD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003468PMC
http://dx.doi.org/10.3390/nu13030999DOI Listing

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