In rats, the pharmacokinetics of 14C-ambazone after i.v. and oral administration was studied. The results demonstrate that the compound is incompletely absorbed from the gastrointestinal tract, penetrates rapidly and to a high degree into various tissues and is preferentially eliminated via the kidneys. After i.v. administration of 50 mg/kg b.m. disposition half-life in whole blood is about 6-7 h. The extent of absorption from the gastrointestinal tract is about 40%.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
pharmacokinetics 14c-ambazone
8
gastrointestinal tract
8
14c-ambazone rats
4
rats rats
4
rats pharmacokinetics
4
14c-ambazone oral
4
oral administration
4
administration studied
4
studied demonstrate
4
demonstrate compound
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!