AI Article Synopsis
- This study examined oropharyngeal and anorectal bacterial isolates in men who have sex with men, identifying both pathogenic and nonpathogenic strains.
- A significant number of these strains showed resistance to two antibiotics, azithromycin and ceftriaxone, with whole genome sequencing revealing mutations linked to reduced susceptibility.
- The discovery of a new antimicrobial resistance mechanism in nonpathogenic strains, potentially transferable to pathogenic ones, raises public health concerns and highlights the importance of genomic surveillance.
Article Abstract
In this study, we characterized all oropharyngeal and anorectal isolates of spp. in a cohort of men who have sex with men. This resulted in a panel of pathogenic ( [n = 5] and [n = 5]) and nonpathogenic ( [n = 11], [n = 3] and [n = 2]). A high proportion of strains in this panel were resistant to azithromycin (18/26) and ceftriaxone (3/26). Whole genome sequencing (WGS) of these strains identified numerous mutations that are known to confer reduced susceptibility to azithromycin and ceftriaxone in . The presence or absence of these known mutations did not explain the high level resistance to azithromycin (>256 mg/L) in the nonpathogenic isolates (8/16). After screening for antimicrobial resistance (AMR) genes, we found a ribosomal protection protein, Msr(D), in these highly azithromycin resistant nonpathogenic strains. The complete integration site originated from and is associated with high level resistance to azithromycin in many other bacterial species. This novel AMR resistance mechanism to azithromycin in nonpathogenic could be a public health concern if it were to be transmitted to pathogenic . This study demonstrates the utility of WGS-based surveillance of nonpathogenic .
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005064 | PMC |
| http://dx.doi.org/10.3390/pathogens10030384 | DOI Listing |
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