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Filename: drivers/Session_files_driver.php
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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
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Filename: models/Detail_model.php
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Function: strpos
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Function: insertAPISummary
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Filename: helpers/my_audit_helper.php
Line Number: 8919
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File: /var/www/html/application/helpers/my_audit_helper.php
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Function: str_replace
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Function: formatAIDetailSummary
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Filename: controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Filename: controllers/Detail.php
Line Number: 256
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Line: 256
Function: _error_handler
File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Background: Intestinal microbiota dysbiosis may enhance the carcinogenicity of colon cancer (CC) by the proliferation and differentiation of epithelial cells. Oral () and () have the ability to invade the gut epithelium, promoting tumor progression. The aim of the study was to assess whether the abundance of these odontopathogenic bacteria was associated with colon cancer. We also investigated how lifestyle factors could influence the oral and abundance and CC.
Methods: Thirty-six CC patients were included in the study to assess the and oral and colon tissue abundance by qPCR. Oral health data, food habits and lifestyles were also recorded.
Results: Patients had a greater quantity of in the oral cavity than matched CC and adjacent non-neoplastic mucosa (adj t) tissues ( = 0.004 and < 0.001). Instead, was not significantly detected in colonic tissues. There was an association between the quantity in the oral and CC tissue and a statistically significant relation between the abundance in adenocarcinoma (ADK) and staging ( = 0.016). The statistical analysis revealed a tendency towards a greater quantity in CC ( = 0.073, η = 0.12) for high-meat consumers.
Conclusion: In our study, was absent in colon tissues but was correlated with the oral inflammation gingival and plaque indices. For the first time, there was evidence that the oral concentration can influence colon tissue concentrations and predict CC prognosis.
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http://dx.doi.org/10.3390/cancers13051032 | DOI Listing |
BMJ Case Rep
December 2024
Hepatopancreatobiliary Unit, Department of Surgery, Changi General Hospital, Singapore.
Biochim Biophys Acta Rev Cancer
December 2024
Gwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea. Electronic address:
The gut microbiome, a complex community of trillions of microorganisms in the intestines, is crucial in maintaining human health. Recent advancements in microbiome research have unveiled a compelling link between the gut microbiome and cancer development and progression. Alterations in the composition and function of the gut microbiome, known as dysbiosis, have been implicated in various types of cancer, including, esophageal, liver, colon, pancreatic, and gastrointestinal.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
December 2024
Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
There has been an increase in the incidence and poor prognosis of colorectal cancer in recent years. In several studies, piperine has been shown to inhibit colon cancer cell growth and induce apoptosis. This study aimed to investigate whether a novel piperine-derived compound, HJ-23 (2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4-(2,4-difluorophenyl)piperazin-1-yl)methanone), can effectively inhibit the development of colorectal cancer through specific molecular mechanisms.
View Article and Find Full Text PDFAm J Surg
December 2024
Department of Surgery, Northwestern University Feinberg School of Medicine, USA.
Background: Nearly a billion people worldwide risk Financial Catastrophe (FC) due to Out-of-Pocket (OOP) health expenditures. With Low-and-Middle-Income Countries (LMICs) disproportionately impacted, and the global burden of colorectal cancer (CRC) expected to increase 60 % by 2030, Nigeria is of interest. This study aims to evaluate the cost of treating CRC at Nigeria's first private cancer center.
View Article and Find Full Text PDFBioorg Chem
December 2024
Department of Photochemistry (Synthetic Unit), Chemical Industries Research Institute, National Research Centre, Cairo 12622, Egypt. Electronic address:
An efficient synthesis of a series of uracil analogous was performed to obtain new potential anticancer agents. The cytotoxic effect of the synthesized derivatives was assessed in vitro against three cancer cell lines, namely hepatic cancer (HepG-2), colon cancer (HCT-116), and breast cancer (MCF-7). Among the tested compounds, 5, 11 and 15 stood as potent uracil derivatives with pan cytotoxicity against the 3 cell lines out-performing the reference compound 5-FU.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!