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5-Aryl-1-Arylideneamino-1-Imidazole-2(3)-Thiones: Synthesis and In Vitro Anticancer Evaluation. | LitMetric
A novel series of arylidene amino imidazole-2-thiones were synthesized, identified using IR, H-NMR, and C-NMR spectral data. Cytotoxic effect of the prepared compounds was carried out utilizing three cancer cell lines; MCF-7 breast cancer, HepG2 liver cancer, and HCT-116 colon cancer cell lines. Imidazole derivative was the most potent of all against three cell lines. DNA flow cytometric analysis showed that, imidazoles and exhibit pre-G1 apoptosis and cell cycle arrest at G2/M phase. The results of the VEGFR-2 and B-Raf kinase inhibition assay revealed that compounds and displayed good inhibitory activity compared with reference drug erlotinib.
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