AI Article Synopsis
- Diminished lymphatic function and abnormal structure often occur in chronic inflammatory diseases, leading researchers to explore ways to enhance inflammation resolution to improve lymphatic health.
- Specialized pro-resolving mediators (SPMs) play a key role in managing inflammation by regulating immune cell activity and various immune processes.
- The text reviews how the lymphatic system is involved in inflammation resolution, examines the link between SPMs and lymphatics, and considers the potential of using SPM therapy to improve lymphatic function and alleviate chronic inflammatory diseases.
Article Abstract
Diminished lymphatic function and abnormal morphology are common in chronic inflammatory diseases. Recent studies are investigating whether it is possible to target chronic inflammation by promoting resolution of inflammation, in order to enhance lymphatic function and attenuate disease. Resolution of inflammation is an active process regulated by bioactive lipids known as specialized pro-resolving mediators (SPMs). SPMs can modulate leukocyte migration and function, alter cytokine/chemokine release, modify autophagy, among other immune-related activities. Here, we summarize the role of the lymphatics in resolution of inflammation and lymphatic impairment in chronic inflammatory diseases. Furthermore, we discuss the current literature describing the connection between SPMs and the lymphatics, and the possibility of targeting the lymphatics with innovative SPM therapy to promote resolution of inflammation and mitigate disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963193 | PMC |
| http://dx.doi.org/10.3390/ijms22052750 | DOI Listing |
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