The emergence of extended-spectrum cephalosporin (ESC)-resistant Gram-negative bacteria is of great concern in both human and veterinary medicine. The aim of this study was to investigate ESC-resistant bacterial isolates from companion animals in South Korea between 2017 and 2019. Isolates with ESC resistance genes, which were identified by PCR, were assessed for genetic relatedness by multi-locus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). In total, 91 ESC-resistant spp., spp., and isolates harbored the gene. Among other ESC resistance genes, , , and were predominantly detected in isolates, whereas and were more frequently detected in isolates. In addition, all -positive isolates were classified as . From the MLST results, -carrying ST131, -carrying ST405, and -carrying ST3285 strains were dominant among isolates. ST273 and ST275 strains harboring were frequently detected in isolates. Various sequence types were obtained in and isolates. All isolates demonstrated unique PFGE profiles (<57-98% similarity) and were unlikely to be derived from a single clone. The present study reveals the presence and wide genetic distribution of ESC-resistant bacterial species in South Korean companion animals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001212 | PMC |
| http://dx.doi.org/10.3390/antibiotics10030249 | DOI Listing |
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