The main hypothesis for the aetiology of meningoencephalitis of unknown origin (MUO) in dogs is an autoimmune or genetic cause that is associated with a triggering event (environmental factors/infectious agents). The aim of this ambispective cohort study was to test for infection in the blood and cerebrospinal fluid (CSF) of dogs with MUO in an endemic area of canine leishmaniosis. Dogs with MUO were selected amongst all dogs undergoing blood anti- antibody testing (control group). The blood plasma or serum samples from all dogs were analysed for anti- antibodies by a quantitative indirect fluorescent assay (IFAT). In dogs with MUO, CSF samples were obtained for analysed by PCR detection of DNA. Forty-four percent and 22% of the dogs in the MUO group featured magnetic resonance imaging (MRI) findings and CSF cytology respectively, consistent with infection. IFAT, PCR, and histological findings were negative for A significant difference in infection prevalence was found between the control and MUO group ( = 0.0022). While it seems unlikely that plays a role in the aetiology of MUO, in endemic areas, this pathogen should be included in the differential diagnosis of this neurological disorder.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998340 | PMC |
| http://dx.doi.org/10.3390/microorganisms9030571 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Canine medial retropharyngeal lymph node measurements on T2 spin-echo sequences at 3T.
Front Vet Sci
December 2024
School of Veterinary Medicine and Biomedical Sciences, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, United States.
Introduction: The objective of this study is to estimate reference values for medial retropharyngeal lymph nodes (MRLNs) measured in high-field (3T) MRI studies of the canine head/brain using transverse T2 spin-echo images and to determine if dogs with structural brain disease exhibit medial retropharyngeal lymph nodes that are larger than expected from estimated reference values.
Methods: The study population comprises 142 MRLNs from 71 dogs with no evidence of structural brain disease and normal CSF evaluation and 116 MRLNs from 58 dogs with structural brain disease confirmed by histopathology as of infectious or neoplastic origin, or to represent meningoencephalitis of unknown etiology.
Results: Based on this sample, MRLNs are expected to measure 2.
Exploring brain perfusion in dogs with meningoencephalitis of unknown origin: A promising role for arterial spin labeling imaging.
J Vet Intern Med
December 2024
Unit of Diagnostic Imaging, Centre Hospitalier Vétérinaire ADVETIA, Vélizy-Villacoublay, France.
Background: Arterial spin labeling (ASL) is a noninvasive brain perfusion magnetic resonance imaging (MRI) technique that has not been assessed in dogs with meningoencephalitis of unknown origin (MUO).
Hypothesis/objectives: Assess brain perfusion changes characteristics before and after medical treatment, and investigate the role of ASL perfusion in the diagnosis and prognosis of MUO in dogs.
Animals: Thirty-one dogs with presumed MUO.
Necrotizing Meningoencephalitis (NME), a form of Meningoencephalitis of Unknown Origin (MUO), is a progressive neuroinflammatory disease that primarily affects young, small-breed dogs. Due to limited understanding of its pathophysiology, early detection and the development of targeted therapies remain challenging. Definitive ante-mortem diagnosis is often unfeasible, and dogs with NME are frequently grouped under the broader MUO category.
View Article and Find Full Text PDFOf potential new treatment targets and polythetic approach in meningoencephalitis of unknown origin: a review.
Front Vet Sci
October 2024
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Meningoencephalitis of unknown origin (MUO) represents an umbrella term for inflammatory, non-infectious central nervous system (CNS) diseases in dogs. Current therapeutic approaches, involving long-term glucocorticosteroid use, often fail to provide adequate relief or cure, and the effectiveness of additional immunosuppressive medications remains uncertain. Future advancements in MUO treatment may benefit from patient-specific therapies, potentially enhancing treatment precision, efficacy, and minimizing side effects.
View Article and Find Full Text PDFOn the utility of cerebrospinal fluid biomarkers in canine neurological disorders.
Sci Rep
October 2024
Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská Cesta 9, Bratislava, Slovak Republic.
Article Synopsis
- The study investigated whether certain cerebral biomarkers (NfL, amyloid-β, tau, NSE) can help diagnose common canine neurological diseases.
- Elevated levels of tau, NfL, and NSE were found in dogs with meningoencephalitis (MUO), while dogs with brain tumors showed an increase in tau and NSE but a decrease in amyloid-β.
- No significant changes in these biomarkers were found in dogs with non-infectious myelopathies, suggesting that NfL, tau, and NSE might be valuable indicators for MUO and brain tumors in dogs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!