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The Esterase PfeE, the Achilles' Heel in the Battle for Iron between and . | LitMetric
Bacteria access iron, a key nutrient, by producing siderophores or using siderophores produced by other microorganisms. The pathogen produces two siderophores but is also able to pirate enterobactin (ENT), the siderophore produced by . ENT-Fe complexes are imported across the outer membrane of by the two outer membrane transporters PfeA and PirA. Iron is released from ENT in the periplasm by hydrolysis of ENT by the esterase PfeE. We show here that gene deletion renders unable to grow in the presence of ENT because it is unable to access iron this siderophore. Two-species co-cultures under iron-restricted conditions show that strongly represses the growth of as long it is able to produce its own siderophores. Both strains are present in similar proportions in the culture as long as the siderophore-deficient strain is able to use ENT produced by to access iron. If is deleted, has the upper hand in the culture and growth is repressed. Overall, these data show that PfeE is the Achilles' heel of in communities with bacteria producing ENT.
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