AI Article Synopsis
- There is currently no cure for women with poor ovarian response (POR) infertility, but research has shown that neogenin and its ligand RGMc may play a role in improving follicular development.
- Experimental treatment of mouse ovaries with RGMc resulted in a 40% increase in oocyte count compared to controls, indicating its potential to stimulate ovarian function.
- Further analysis revealed that RGMc enhances the signaling pathway involving prostaglandin D2 (PGD2), suggesting that RGMc could be a viable option for ovarian stimulation in women with POR.
Article Abstract
There is currently no cure for infertility in women with a poor ovarian response (POR). Neogenin is reported to be abundantly expressed in the ovary; however, its role in mammalian follicular development is unclear and its ligand and signaling pathway remain uncertain. We systematically investigated the role of neogenin and the ligand repulsive guidance molecule c (RGMc) during follicular development. We treated hyperstimulated mouse ovaries with RGMc and analyzed follicular development. Furthermore, we investigated clusters of up/downregulated genes in RGMc-treated ovaries using whole-transcriptome next-generation sequencing (NGS). In addition, we investigated whether expression of up/downregulated factors identified by NGS was also altered in cumulus cells (CCs) of patients with a POR. The number of oocytes was 40% higher in RGMc-treated ovaries than in control ovaries. NGS data indicated that prostaglandin D2 (PGD2) was involved in the RGMc signaling pathway during follicular development. RGMc treatment significantly elevated the PGD2 level in culture medium of CCs obtained from patients with a POR. Our results demonstrate that RGMc as neogenin ligand promotes follicular development in ovaries via the PGD2 signaling pathway. Therefore, it may be possible to use RGMc for ovarian stimulation in patients with a POR.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999520 | PMC |
| http://dx.doi.org/10.3390/biomedicines9030280 | DOI Listing |
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