AI Article Synopsis
- The GH/IGF-I axis plays a crucial role in how our bodies manage metabolism, and malnutrition can lower IGF-I levels and affect brown fat's ability to generate heat.
- In experiments with rats, it was found that central leptin infusion altered the levels of specific hormones and impacted the signaling pathways related to brown adipose tissue (BAT) thermogenesis.
- Results indicate that leptin influences the GH/IGF-I axis and that changes in a key protein (UCP-1) related to energy expenditure in brown fat are linked to leptin levels and energy balance in the body.
Article Abstract
The growth hormone (GH)/insulin-like growth factor I (IGF-I) axis is involved in metabolic control. Malnutrition reduces IGF-I and modifies the thermogenic capacity of brown adipose tissue (BAT). Leptin has effects on the GH/IGF-I axis and the function of BAT, but its interaction with IGF-I and the mechanisms involved in the regulation of thermogenesis remains unknown. We studied the GH/IGF-I axis and activation of IGF-I-related signaling and metabolism related to BAT thermogenesis in chronic central leptin infused (L), pair-fed (PF), and control rats. Hypothalamic somatostatin mRNA levels were increased in PF and decreased in L, while pituitary GH mRNA was reduced in PF. Serum GH and IGF-I concentrations were decreased only in PF. In BAT, the association between suppressor of cytokine signaling 3 and the IGF-I receptor was reduced, and phosphorylation of the IGF-I receptor increased in the L group. Phosphorylation of Akt and cyclic AMP response element binding protein and glucose transporter 4 mRNA levels were increased in L and mRNA levels of uncoupling protein-1 (UCP-1) and enzymes involved in lipid anabolism reduced in PF. These results suggest that modifications in UCP-1 in BAT and changes in the GH/IGF-I axis induced by negative energy balance are dependent upon leptin levels.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001882 | PMC |
| http://dx.doi.org/10.3390/ijms22062827 | DOI Listing |
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