Studying the mechanical response of the human thorax submitted to ballistic impact is a challenging field of research. For ethical reasons, it is not possible to perform tests on the human body. Numerical simulations are therefore one of the alternatives for evaluating the mechanical response of the human thorax. In earlier research, a simplified human thorax submitted to low-velocity impacts without ballistic protection was modelled. Not all internal organs in the thorax were taken into account. The only considered organs were the heart, lungs, trachea and aorta, with the space between them being void. The organs were covered by an idealised structure simulating the rib cage, spine and muscles. Such a simplified model was however sufficient in the field of less-lethal impact assessment. Indeed, in this case, only forces and displacements are taken into account. In the field of behind armour blunt trauma (BABT), spherical pressure or shock waves are expected to appear and propagate into internal organs. Nevertheless, the presence of the void space makes it impossible to evaluate the propagation of the considered waves. This paper focuses on a method for filling the void space and making the model more comprehensive. Starting from the initial meshed geometry of this simulated thorax, it uses a coupling between Lagrangian and arbitrary Lagrangian-Eulerian (ALE) objects. Finally, the use of the filled model is extended to a BABT case study. From the simulations, it could be concluded that BABT should be related to "blast" instead of "viscous" solicitations.
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http://dx.doi.org/10.1016/j.jmbbm.2021.104493 | DOI Listing |
Artif Organs
March 2025
The BioRobotics Insitute and Department of Excellence of Robotics & AI, Scuola Superiore Sant'Anna, Pontedera, Italy.
Background: In cardiovascular engineering, the recent introduction of soft robotic technologies sheds new light on the future of implantable cardiac devices, enabling the replication of complex bioinspired architectures and motions. To support human heart function, assistive devices and total artificial hearts have been developed. However, the system's functionality, hemocompatibility, and overall implantability are still open challenges.
View Article and Find Full Text PDFCancer Imaging
March 2025
Radiology, Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, entry 70, 1st floor, Uppsala, 751 85, Sweden.
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View Article and Find Full Text PDFEur J Heart Fail
March 2025
Berlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models to understand the biological basis of their cardiotoxicity.
View Article and Find Full Text PDFBMC Med Res Methodol
March 2025
Department of Hematology, Erasmus Medical Center Cancer Institute, Dr. Molewaterplein 40, Rotterdam, 3015 GD, The Netherlands.
This study explores practices surrounding the operationalization of ethno-racial categories (ERCs) as confounders in biomedical research, with a focus on sickle cell disease (SCD) as a model. ERCs, often aggregate labels encompassing diverse individuals which raises questions about their relevance as confounders. Given SCD's racialization as a "Black" disease, understanding ERC utilization is crucial.
View Article and Find Full Text PDFBMJ Case Rep
March 2025
Department of Radiology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
A male patient in his 70s, who had previously worked as a bricklayer, presented with worsening shortness of breath on exertion and cough for 6 months. He had lost weight, and a respiratory examination suggested a right pleural effusion. Routine evaluation was unremarkable.
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