The evolution from "vessel dominated by heart" of "heart dominating pericardium meridian of hand-" was sorted out. It was the process in which the heart concept was understood from two aspects rather than from one. The statement, "heart dominating pericardium meridian of hand-" is originated from Chapter Ten of (). But such pericardium meridian has not be mentioned in the early bamboo slip and silk, i.e. () and (). "Twelve meridians" unearthed from Laoguanshan is named as the trajectory of "vessel dominated by heart", which was originally recorded for the diseases of heart system. In later evolution, in order to match three hand meridians with two organs in the upper , the ancient physicians proposed the theory as heart dominating meridian, "enveloping heart system" "heart being not be attacked by pathogens" and "pathogen attacking the vessel covered around heart" along with following the records of "twelve meridians" unearthed from Laoguanshan, i.e heart dominating heart system and hand- entering heart. Hence, it stands to reason that heart matches with and the acupoints are selected from the meridian dominated by heart. In this evolution process, "pericardium" is generated and becomes the third organ in the upper , thus the meridian dominated by heart is named as "hand- meridian".

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