Modelling extracellular matrix and cellular contributions to whole muscle mechanics.

PLoS One

Department of Mathematics, Simon Fraser University, Burnaby, British Columbia, Canada.

Published: September 2021

AI Article Synopsis

  • Skeletal muscle tissue is structurally complex, consisting of various components like collagen, actin, and myosin, which can be simplified into a model resembling a nonlinear spring at a basic level.
  • This study aims to create an intermediate physical model that integrates these components to accurately represent the elastic response of muscle, excluding activation-related factors.
  • By determining the volume fractions of each material in muscle tissue, the model will help analyze the impacts of conditions like cerebral palsy and muscular dystrophies on muscle behavior and energy distribution.

Article Abstract

Skeletal muscle tissue has a highly complex and heterogeneous structure comprising several physical length scales. In the simplest model of muscle tissue, it can be represented as a one dimensional nonlinear spring in the direction of muscle fibres. However, at the finest level, muscle tissue includes a complex network of collagen fibres, actin and myosin proteins, and other cellular materials. This study shall derive an intermediate physical model which encapsulates the major contributions of the muscle components to the elastic response apart from activation-related along-fibre responses. The micro-mechanical factors in skeletal muscle tissue (eg. connective tissue, fluid, and fibres) can be homogenized into one material aggregate that will capture the behaviour of the combination of material components. In order to do this, the corresponding volume fractions for each type of material need to be determined by comparing the stress-strain relationship for a volume containing each material. This results in a model that accounts for the micro-mechanical features found in muscle and can therefore be used to analyze effects of neuro-muscular diseases such as cerebral palsy or muscular dystrophies. The purpose of this study is to construct a model of muscle tissue that, through choosing the correct material parameters based on experimental data, will accurately capture the mechanical behaviour of whole muscle. This model is then used to look at the impacts of the bulk modulus and material parameters on muscle deformation and strain energy-density distributions.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018661PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249601PLOS

Publication Analysis

Top Keywords

muscle tissue
20
muscle
11
contributions muscle
8
skeletal muscle
8
model muscle
8
material parameters
8
tissue
6
material
6
model
5
modelling extracellular
4

Similar Publications

Sewage sludge applications as soil amendment call for a proper ecological risk assessment due to unexpected delivery of toxic chemicals and materials. Standardized acute toxicity assays have proven to provide limited information in terms of potential hazard for soil organisms. Here, sublethal endpoints as physiological and tissue alterations were proposed as suitable tools for sewage sludge ecological risk assessment.

View Article and Find Full Text PDF

Mesenchymal Stromal Cell (MSC) Isolation and Induction of Acute and Replicative Senescence.

Methods Mol Biol

December 2024

Department of Experimental Medicine, Biotechnology, and Molecular Biology Section, Luigi Vanvitelli Campania University, Naples, Italy.

Mesenchymal stromal cells (MSCs) are a heterogeneous population of non-hematopoietic adult stem cells derived from the embryonic mesoderm. They possess self-renewal and multipotent differentiation capabilities, allowing them to give rise to mesodermal cell types, such as osteoblasts, chondroblasts, and adipocytes, as well as non-mesodermal cells, including neuron-like cells and endothelial cells. MSCs play a vital role in maintaining homeostasis across various tissues by facilitating tissue repair, immune regulation, and inflammatory response balance.

View Article and Find Full Text PDF

Real-time monitoring of reactive oxygen and nitrogen species (RONS) in skeletal muscle provides crucial insights into the cause-and-effect relationships between physical activity and health benefits. However, the dynamic production of exercise-induced RONS remains poorly explored, due to the lack of sensing tools that can conform to soft skeletal muscle while monitor RONS release during exercise. Here we introduce dual flexible sensors via twisting carbon nanotubes into helical bundles of fibers and subsequent assembling electrochemical sensing components.

View Article and Find Full Text PDF

Purpose: Teprotumumab, a novel human monoclonal antibody, has been shown to reverse the clinical manifestations of thyroid eye disease. Previous reports have suggested that it demonstrates disease-modifying properties through the reduction of orbital fat and muscle volumes. This study aims to analyze orbital volumetric change following treatment and to identify clinical and radiological predictors of response.

View Article and Find Full Text PDF

Flavan-3-ols (FL) are poorly bioavailable astringent polyphenols that induce hyperactivation of the sympathetic nervous system. The aim of this study was to investigate the effects of repeated oral administration of FL on mice hindlimb skeletal muscle using immunohistochemical techniques. C57BL/6J male mice were orally administered 50 mg/kg of FL for a period of 2 weeks, and bromideoxyuridine (BrdU) was administered intraperitoneally 3 days prior to the dissection.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!