Randomized Single-Case Intervention Designs and Analyses for Health Sciences Researchers: A Versatile Clinical Trials Companion.

Aim: An expository note introduces health sciences researchers to randomized single-case intervention designs, an adaptation of interrupted time-series methodology, and the staple of a scientifically credible small-sample research paradigm.

Methods: Detailed examples illustrating two different randomized single-case procedures are presented to highlight the techniques' advantages relative to small-sample nonparametric procedures that are commonly applied in the medical and health sciences fields.

Results: Numerous positive outcomes, based on both statistical simulation studies and actual intervention research investigations, support the applicability and value of these procedures.

Conclusion: Randomized single-case intervention designs are recommended for consideration by health sciences researchers.