AI Article Synopsis
- Protein-restricted (PR) diets have been shown to enhance health and lifespan across various species, but the specific elements responsible for these benefits, particularly branched-chain amino acids (BCAAs), are being investigated.
- Recent research indicates that lowering dietary BCAAs—leucine, isoleucine, and valine—improves survival rates and metabolic health in specific mouse models when initiated in midlife, leading to a notable 30% increase in lifespan among male mice.
- The findings suggest that BCAA restriction could be a promising strategy for promoting healthy aging, emphasizing its potential as a practical intervention.
Article Abstract
Protein restricted (PR) diets promote health and longevity in many species. While the precise components of a PR diet that mediate the beneficial effects to longevity have not been defined, we recently showed that many metabolic effects of PR can be attributed to reduced dietary levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine. Here, we demonstrate that restricting dietary BCAAs increases the survival of two different progeroid mouse models, delays frailty and promotes the metabolic health of wild-type C57BL/6J mice when started in midlife, and leads to a 30% increase in lifespan and a reduction in frailty in male, but not female, wild-type mice when fed lifelong. Our results demonstrate that restricting dietary BCAAs can increase healthspan and longevity in mice, and suggest that reducing dietary BCAAs may hold potential as a translatable intervention to promote healthy aging.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009080 | PMC |
| http://dx.doi.org/10.1038/s43587-020-00006-2 | DOI Listing |
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