Urinary Incontinence (UI) in women is a very common disease. Given the shortage of epidemiological and clinical data in our environment, we here provide an update on the status of this disease and its management at the University Clinics of Kinshasa. We conducted a descriptive study in the University Clinics of Kinshasa from January 2015 to December 2016. The annual rate of IU was 1.3% (23/1813 patients). We included 15 cases whose medical files were usable and whose average age was 49.2±20.5 years, ranging between 15 and 98 years. IU affected multiparous women (53.4%), pauciparous women (26.7%), primiparous women (6.7%) and nulliparous women (13.3%) and the median date of onset of IU was 3 months. Urge incontinence affected 33.3% of patients and effort incontinence 13.3%. Among diagnoses associated with UI, the most common were urogenital infections (46.7%), cystocele (20%) and chronic pelvic pain (20%). These patients received antibiotic therapy (60%), anticholinergics drugs (20%), and pelviperineal rehabilitation (20%) as well as surgical treatment. UI is underestimated at the University Clinics of Kinshasa. The most commonly diagnosed IUs are effort and urge incontinence. Patient´s management is based on multidisciplinary approach.
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http://dx.doi.org/10.11604/pamj.2020.37.386.18036 | DOI Listing |
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Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States of America.
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Department of Laboratory Medicine, Division of Translational Cancer Researc, Lund University Cancer Centre, Lund University, Lund, Sweden.
The biology centered around the TGF-beta type I receptor Activin Receptor-Like Kinase (ALK)1 (encoded by ACVRL1) has been almost exclusively based on its reported endothelial expression pattern since its first functional characterization more than two decades ago. Here, in efforts to better define the therapeutic context in which to use ALK1 inhibitors, we uncover a population of tumor-associated macrophages (TAMs) that, by virtue of their unanticipated Acvrl1 expression, are effector targets for adjuvant anti-angiogenic immunotherapy in mouse models of metastatic breast cancer. The combinatorial benefit depended on ALK1-mediated modulation of the differentiation potential of bone marrow-derived granulocyte-macrophage progenitors, the release of CD14+ monocytes into circulation, and their eventual extravasation.
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Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Centre, 3901 Rainbow Blvd, MS3002, Kansas City, KS, USA.
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JMIR Form Res
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Center for Cancer Health Equity, Rutgers Cancer Institute, New Brunswick, NJ, United States.
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