The potent spliceosome modulator pladienolide B, which bears 10 stereogenic centers, is prepared in 10 steps (LLS). Asymmetric alcohol-mediated carbonyl crotylations catalyzed by ruthenium and iridium that occur with syn- and anti-diastereoselectivity, respectively, were used to form the C20-C21 and C10-C11 C-C bonds.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190871 | PMC |
| http://dx.doi.org/10.1002/anie.202103845 | DOI Listing |
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